The Role of Platelets in Sepsis

Overview

Journal Res Pract Thromb Haemost

Publisher Elsevier

Date 2021 Feb 4

PMID 33537527

Citations 29

Authors

Oonagh Shannon

Affiliations

Soon will be listed here.

Abstract

A State of the Art lecture titled "The role of platelets in sepsis" was presented at the ISTH congress in 2020. Sepsis is a life-threatening organ dysfunction caused by a dysregulated and multifaceted host response to infection. Platelets play a significant role in the coordinated immune response to infection and therefore in the inflammation and coagulation dysfunction that contributes to organ damage in sepsis. Thrombocytopenia has a high incidence in sepsis, and it is a marker of poor prognosis. The genesis of thrombocytopenia is likely multifactorial, and unraveling the involved molecular mechanisms will allow development of biomarkers of platelet function in sepsis. Such platelet biomarkers can facilitate study of antiplatelet interventions as immunomodulatory treatment in sepsis. Finally, relevant new data on this topic presented during the 2020 ISTH virtual congress are reviewed.

Citing Articles

The Correlation of Hemostatic Parameters with the Development of Early Sepsis-Associated Encephalopathy. A Retrospective Observational Study.

Scarlatescu F, Scarlatescu E, Tomescu D, Bartos D J Crit Care Med (Targu Mures). 2025; 10(4):329-336.

PMID: 39829725 PMC: 11740703. DOI: 10.2478/jccm-2024-0040.

Immune cell composition and its impact on prognosis in children with sepsis.

Wang H, Guo C, Wang Y, Li C, Wu Y, Ren X BMC Pediatr. 2024; 24(1):611.

PMID: 39342149 PMC: 11438221. DOI: 10.1186/s12887-024-05087-1.

Red ginseng extract inhibits lipopolysaccharide-induced platelet-leukocyte aggregates in mice.

Lee Y, Kim S, Park J, Lee W, Han J, Seo M J Ginseng Res. 2024; 48(4):428-434.

PMID: 39036730 PMC: 11258389. DOI: 10.1016/j.jgr.2024.03.009.

Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1β production, VWF release and NET deposition in the myocardium.

Heger L, Schommer N, Van Bruggen S, Sheehy C, Chan W, Wagner D Sci Rep. 2024; 14(1):14524.

PMID: 38914598 PMC: 11196583. DOI: 10.1038/s41598-024-64710-4.

Deciphering Abnormal Platelet Subpopulations in COVID-19, Sepsis and Systemic Lupus Erythematosus through Machine Learning and Single-Cell Transcriptomics.

Qiu X, Nair M, Jaroszewski L, Godzik A Int J Mol Sci. 2024; 25(11).

PMID: 38892129 PMC: 11173046. DOI: 10.3390/ijms25115941.

References

Adamzik M, Gorlinger K, Peters J, Hartmann M . Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis. Crit Care. 2012; 16(5):R204. PMC: 3682307. DOI: 10.1186/cc11816. View

Jenne C, Kubes P . Platelets in inflammation and infection. Platelets. 2015; 26(4):286-92. DOI: 10.3109/09537104.2015.1010441. View

Scicluna B, van Vught L, Zwinderman A, Wiewel M, Davenport E, Burnham K . Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med. 2017; 5(10):816-826. DOI: 10.1016/S2213-2600(17)30294-1. View

Watson C, Kerrigan S, Cox D, Henderson I, Watson S, Arman M . Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets. 2016; 27(6):535-40. PMC: 5000871. DOI: 10.3109/09537104.2016.1148129. View

Wong C, Jenne C, Petri B, Chrobok N, Kubes P . Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol. 2013; 14(8):785-92. PMC: 4972575. DOI: 10.1038/ni.2631. View

Gawaz M, Dickfeld T, Bogner C, Fateh-Moghadam S, Neumann F . Platelet function in septic multiple organ dysfunction syndrome. Intensive Care Med. 1997; 23(4):379-85. DOI: 10.1007/s001340050344. View

Hotchkiss R, Monneret G, Payen D . Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013; 13(12):862-74. PMC: 4077177. DOI: 10.1038/nri3552. View

Damien P, Cognasse F, Eyraud M, Arthaud C, Pozzetto B, Garraud O . LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand. BMC Immunol. 2015; 16:3. PMC: 4322959. DOI: 10.1186/s12865-015-0067-2. View

Ivanov I, Apta B, Bonna A, Harper M . Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes. Sci Rep. 2019; 9(1):13397. PMC: 6746844. DOI: 10.1038/s41598-019-49635-7. View

10.

Svensson L, Baumgarten M, Morgelin M, Shannon O . Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates, from which bacteria subsequently escape. Infect Immun. 2014; 82(10):4307-14. PMC: 4187850. DOI: 10.1128/IAI.02020-14. View

11.

Gaertner F, Massberg S . Blood coagulation in immunothrombosis-At the frontline of intravascular immunity. Semin Immunol. 2016; 28(6):561-569. DOI: 10.1016/j.smim.2016.10.010. View

12.

Seidel M, Winning J, Claus R, Bauer M, Losche W . Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis. J Thromb Haemost. 2009; 7(6):1030-2. DOI: 10.1111/j.1538-7836.2009.03352.x. View

13.

Broadley S, Plaumann A, Coletti R, Lehmann C, Wanisch A, Seidlmeier A . Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity. Cell Host Microbe. 2016; 20(1):36-48. DOI: 10.1016/j.chom.2016.05.023. View

14.

Singer M, Deutschman C, Seymour C, Shankar-Hari M, Annane D, Bauer M . The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8):801-10. PMC: 4968574. DOI: 10.1001/jama.2016.0287. View

15.

Guo L, Rondina M . The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases. Front Immunol. 2019; 10:2204. PMC: 6753373. DOI: 10.3389/fimmu.2019.02204. View

16.

Carestia A, Davis R, Davis L, Jenne C . Inhibition of immunothrombosis does not affect pathogen capture and does not promote bacterial dissemination in a mouse model of sepsis. Platelets. 2019; 31(7):925-931. DOI: 10.1080/09537104.2019.1704711. View

17.

McDonald B, Davis R, Kim S, Tse M, Esmon C, Kolaczkowska E . Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood. 2017; 129(10):1357-1367. PMC: 5345735. DOI: 10.1182/blood-2016-09-741298. View

18.

Shibazaki M, Kawabata Y, Yokochi T, Nishida A, Takada H, Endo Y . Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides. Infect Immun. 1999; 67(10):5186-91. PMC: 96869. DOI: 10.1128/IAI.67.10.5186-5191.1999. View

19.

Mohanty T, Fisher J, Bakochi A, Neumann A, Cardoso J, Karlsson C . Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis. Nat Commun. 2019; 10(1):1667. PMC: 6458182. DOI: 10.1038/s41467-019-09040-0. View

20.

Wegrzyn G, Walborn A, Rondina M, Fareed J, Hoppensteadt D . Biomarkers of Platelet Activation and Their Prognostic Value in Patients With Sepsis-Associated Disseminated Intravascular Coagulopathy. Clin Appl Thromb Hemost. 2021; 27:1076029620943300. PMC: 7894689. DOI: 10.1177/1076029620943300. View