Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Feb 4

PMID 33535574

Citations 15

Authors

Kai-Xuan Wang

Wen-Wen Cui

Xu Yang

Ai-Bin Tao

Ting Lan

Tao-Sheng Li

Lan Luo

Affiliations

Soon will be listed here.

Abstract

Radiation therapy for cancers also damages healthy cells and causes side effects. Depending on the dosage and exposure region, radiotherapy may induce severe and irreversible injuries to various tissues or organs, especially the skin, intestine, brain, lung, liver, and heart. Therefore, promising treatment strategies to mitigate radiation injury is in pressing need. Recently, stem cell-based therapy generates great attention in clinical care. Among these, mesenchymal stem cells are extensively applied because it is easy to access and capable of mesodermal differentiation, immunomodulation, and paracrine secretion. Here, we summarize the current attempts and discuss the future perspectives about mesenchymal stem cells (MSCs) for mitigating radiotherapy side effects.

Citing Articles

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Influence of Super-Low-Intensity Microwave Radiation on Mesenchymal Stem Cells.

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Transcriptomic analysis of BM-MSCs identified EGR1 as a transcription factor to fully exploit their therapeutic potential.

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