Relationship Between Urine Specific Gravity and the Prevalence Rate of Kidney Stone

Overview

Journal Transl Androl Urol

Date 2021 Feb 3

PMID 33532308

Citations 8

Authors

Weipu Mao

Hui Zhang

Zhipeng Xu

Jiang Geng

Ziwei Zhang

Jianping Wu

Bin Xu

Ming Chen

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to evaluate the relationship between urine specific gravity (USG) and the prevalence rate of kidney stone.

Methods: We conducted a cross-sectional study of adult participants (≥20 years) of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2008. The USG was divided into three groups: <1.008, 1.008-1.020 and >1.020. Univariate and multivariate logistic regression analysis was used to determine the effect of USG on the prevalence rate of kidney stone.

Results: A total of 4,791 patients were included in this study, of which 464 (9.7%) reported a history of kidney stone. Univariate logistic regression analysis showed that age, gender, race, hypertension, diabetes, body mass index (BMI), estimated glomerular filtration rate (eGFR), USG and urine creatinine were closely related to the prevalence of kidney stones. After adjusting for known confounding factors, multivariate logistic regression showed that the prevalence rate of kidney stone increased with the increase of USG (1.008-1.020 <1.008, OR =1.31, 95% CI, 0.09-1.91, P=0.155; >1.020 <1.008, OR =1.71, 95% CI, 1.16-2.54, P=0.007).

Conclusions: The increase of USG was significantly correlated with self-reported kidney stone. This finding helps to identify risk factors for kidney stones as early as possible in the United States.

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