Semi-Crystalline Copolymer Hydrogels As Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Feb 3

PMID 33530287

Citations 8

Authors

Snezana Ilic-Stojanovic

Ljubisa Nikolic

Vesna Nikolic

Slobodan Petrovic

Violeta Oro

Zarko Mitic

Stevo Najman

Affiliations

Soon will be listed here.

Abstract

In this study, poly(-isopropylacrylamide--2-hydroxypropyl methacrylate) hydrogels were synthesized using free radical initiated copolymerization method. Four hydrogels with different cross-linker concentrations were prepared. Semi-crystalline, cross-linked copolymer networks were confirmed by FTIR, SEM and XRD analysis. Variation of swelling behaviour was monitored gravimetrically and thermo-responsiveness has been noticed. An application of synthesized thermo-responsive hydrogels as carriers for the modulated release of anti-inflammatory model drug was investigated. Moreover, naproxen loading into these hydrogels was also determined using FTIR, SEM and XRD techniques and release was analyzed using HPLC method at simulated physiological conditions. Swelling kinetic and mechanism of water transport, as well as diffusion of naproxen through the hydrogels were analyzed. Thus, the aim of this work was to study various compositions of obtained hydrogels and their possibility of application as a thermo-responsive carrier for prolonged naproxen release in order to evaluate as a potential candidate for drug carrier in future pharmaceutical applications.

Citing Articles

Temperature-Sensitive Hydrogels as Carriers for Modulated Delivery of Acetaminophen.

Ilic-Stojanovic S, Nikolic L, Nikolic V, Ristic I, Cakic S, Petrovic S Gels. 2023; 9(9).

PMID: 37754365 PMC: 10530087. DOI: 10.3390/gels9090684.

Synthesis, Thermogravimetric Analysis, and Kinetic Study of Poly--Isopropylacrylamide with Varied Initiator Content.

Gola A, Knysak T, Mucha I, Musial W Polymers (Basel). 2023; 15(11).

PMID: 37299226 PMC: 10255422. DOI: 10.3390/polym15112427.

The Formulation of Curcumin: 2-Hydroxypropyl-β-cyclodextrin Complex with Smart Hydrogel for Prolonged Release of Curcumin.

Nikolic L, Urosevic M, Nikolic V, Gajic I, Dinic A, Miljkovic V Pharmaceutics. 2023; 15(2).

PMID: 36839703 PMC: 9967663. DOI: 10.3390/pharmaceutics15020382.

Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery.

Ilic-Stojanovic S, Nikolic L, Nikolic V, Ristic I, Cakic S, Petrovic S Gels. 2023; 9(1).

PMID: 36661836 PMC: 9858263. DOI: 10.3390/gels9010070.

Macro- and Nanoscale Effect of Ethanol on Bovine Serum Albumin Gelation and Naproxen Release.

Sanaeifar N, Mader K, Hinderberger D Int J Mol Sci. 2022; 23(13).

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