Role of NLRs in the Regulation of Type I Interferon Signaling, Host Defense and Tolerance to Inflammation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Feb 2

PMID 33525590

Citations 17

Authors

Ioannis Kienes

Tanja Weidl

Nora Mirza

Mathias Chamaillard

Thomas A Kufer

Affiliations

Soon will be listed here.

Abstract

Type I interferon signaling contributes to the development of innate and adaptive immune responses to either viruses, fungi, or bacteria. However, amplitude and timing of the interferon response is of utmost importance for preventing an underwhelming outcome, or tissue damage. While several pathogens evolved strategies for disturbing the quality of interferon signaling, there is growing evidence that this pathway can be regulated by several members of the Nod-like receptor (NLR) family, although the precise mechanism for most of these remains elusive. NLRs consist of a family of about 20 proteins in mammals, which are capable of sensing microbial products as well as endogenous signals related to tissue injury. Here we provide an overview of our current understanding of the function of those NLRs in type I interferon responses with a focus on viral infections. We discuss how NLR-mediated type I interferon regulation can influence the development of auto-immunity and the immune response to infection.

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References

Yan H, Krishnan K, Greenlund A, Gupta S, Lim J, Schreiber R . Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 1996; 15(5):1064-74. PMC: 450004. View

Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L . An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003; 4(7):702-7. DOI: 10.1038/ni945. View

Hwang I, Scott J, Kakarla T, Duriancik D, Choi S, Cho C . Activation mechanisms of natural killer cells during influenza virus infection. PLoS One. 2013; 7(12):e51858. PMC: 3534084. DOI: 10.1371/journal.pone.0051858. View

Ataide M, Andrade W, Zamboni D, Wang D, Souza M, Franklin B . Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 2014; 10(1):e1003885. PMC: 3894209. DOI: 10.1371/journal.ppat.1003885. View

Yin H, Sun G, Yang Q, Chen C, Qi Q, Wang H . NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway. Sci Rep. 2017; 7:44311. PMC: 5347132. DOI: 10.1038/srep44311. View

Benko S, Magalhaes J, Philpott D, Girardin S . NLRC5 limits the activation of inflammatory pathways. J Immunol. 2010; 185(3):1681-91. DOI: 10.4049/jimmunol.0903900. View

Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y . The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling. J Biol Chem. 2018; 293(8):2701-2710. PMC: 5827450. DOI: 10.1074/jbc.RA117.000152. View

Bruey J, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed J . PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. J Biol Chem. 2004; 279(50):51897-907. DOI: 10.1074/jbc.M406741200. View

Ma Z, Hopcraft S, Yang F, Petrucelli A, Guo H, Ting J . NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency. PLoS Pathog. 2017; 13(5):e1006350. PMC: 5426799. DOI: 10.1371/journal.ppat.1006350. View

10.

Kvarnhammar A, Petterson T, Cardell L . NOD-like receptors and RIG-I-like receptors in human eosinophils: activation by NOD1 and NOD2 agonists. Immunology. 2011; 134(3):314-25. PMC: 3209571. DOI: 10.1111/j.1365-2567.2011.03492.x. View

11.

Boxx G, Cheng G . The Roles of Type I Interferon in Bacterial Infection. Cell Host Microbe. 2016; 19(6):760-9. PMC: 5847370. DOI: 10.1016/j.chom.2016.05.016. View

12.

Amer A, Franchi L, Kanneganti T, Body-Malapel M, Ozoren N, Brady G . Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem. 2006; 281(46):35217-23. DOI: 10.1074/jbc.M604933200. View

13.

Vladimer G, Weng D, Paquette S, Vanaja S, Rathinam V, Aune M . The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012; 37(1):96-107. PMC: 3753114. DOI: 10.1016/j.immuni.2012.07.006. View

14.

Chamaillard M, Philpott D, Girardin S, Zouali H, Lesage S, Chareyre F . Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A. 2003; 100(6):3455-60. PMC: 152314. DOI: 10.1073/pnas.0530276100. View

15.

Buchmeier N, Schreiber R . Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci U S A. 1985; 82(21):7404-8. PMC: 391353. DOI: 10.1073/pnas.82.21.7404. View

16.

Lei Y, Wen H, Yu Y, Taxman D, Zhang L, Widman D . The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 2012; 36(6):933-46. PMC: 3397828. DOI: 10.1016/j.immuni.2012.03.025. View

17.

Niesel D, Hess C, Cho Y, Klimpel K, Klimpel G . Natural and recombinant interferons inhibit epithelial cell invasion by Shigella spp. Infect Immun. 1986; 52(3):828-33. PMC: 260934. DOI: 10.1128/iai.52.3.828-833.1986. View

18.

Watanabe T, Asano N, Fichtner-Feigl S, Gorelick P, Tsuji Y, Matsumoto Y . NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest. 2010; 120(5):1645-62. PMC: 2860924. DOI: 10.1172/JCI39481. View

19.

Tong Y, Cui J, Li Q, Zou J, Wang H, Wang R . Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 2012; 22(5):822-35. PMC: 3343662. DOI: 10.1038/cr.2012.53. View

20.

ULUSOY E, Cayan S, Yilmaz N, Aktas S, Acar D, Doruk E . Interferon alpha-2b may impair testicular histology including spermatogenesis in a rat model. Arch Androl. 2004; 50(5):379-85. DOI: 10.1080/01485010490474823. View