The Effect of the Local Administration of Biological Substances on the Rate of Orthodontic Tooth Movement: a Systematic Review of Human Studies

Overview

Journal Prog Orthod

Publisher Springer

Specialty Dentistry

Date 2021 Feb 1

PMID 33523325

Citations 12

Authors

Sarah Abu Arqub

Vaibhav Gandhi

Marissa G Iverson

Maram Ahmed

Chia-Ling Kuo

Jinjian Mu

Eliane Dutra

Flavio Uribe

Affiliations

Soon will be listed here.

Abstract

Background: The influence of different biological agents on the rate of orthodontic tooth movement (OTM) has been extensively reviewed in animal studies with conflicting results. These findings cannot be extrapolated from animals to humans. Therefore, we aimed to systematically investigate the most up-to-date available evidence of human studies regarding the effect of the administration of different biological substances on the rate of orthodontic tooth movement.

Methods: A total of 8 databases were searched until the 16th of June 2020 without restrictions. Controlled randomized and non-randomized human clinical studies assessing the effect of biological substances on the rate of OTM were included. ROBINS-I and the Cochrane Risk of Bias tools were used. Reporting of this review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results: A total of 11 studies (6 randomized clinical trials and 5 prospective clinical trials) were identified for inclusion. Local injections of prostaglandin E1 and vitamin C exerted a positive influence on the rate of OTM; vitamin D showed variable effects. The use of platelet-rich plasma and its derivatives showed inconsistent results, while the local use of human relaxin hormone showed no significant effects on the rate of OTM.

Limitations: The limited and variable observation periods after the administration of the biological substances, the high and medium risk of bias assessment for some included studies, the variable concentrations of the assessed biological agents, the different experimental designs and teeth evaluated, and the variety of measurement tools have hampered the quantitative assessment of the results as originally planned.

Conclusions And Implications: Despite the methodological limitations of the included studies, this systematic review provides an important overview of the effects of a variety of biological agents on the rate of tooth movement and elucidates the deficiencies in the clinical studies that have been conducted so far to evaluate the effectiveness of these agents in humans, providing some guidelines for future robust research.

Trial Registration: PROSPERO ( CRD42020168481 , www.crd.york.ac.uk/prospero ).

Citing Articles

"Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial".

Kumar D, Mn R, Sharma R, Sachdeva A, Bhupali N, Solanki R J Oral Biol Craniofac Res. 2025; 15(2):281-287.

PMID: 40027853 PMC: 11869107. DOI: 10.1016/j.jobcr.2025.01.017.

Effectiveness of Platelet Rich Fibrin in Accelerating Canine Distal Movement: A Systematic Review of Randomized Controlled Trials.

Singh S, Jain R, Selvaraj A, Balasubramaniam A Cureus. 2024; 16(9):e69184.

PMID: 39398760 PMC: 11468908. DOI: 10.7759/cureus.69184.

Assessing the Effect of Exogenous Melatonin on Orthodontic Tooth Movement.

Thiagarajan S, Gopalakrishnan U Cureus. 2024; 16(7):e65885.

PMID: 39219898 PMC: 11364488. DOI: 10.7759/cureus.65885.

Enhancement of Orthodontic Tooth Movement by Local Administration of Biofunctional Molecules: A Comprehensive Systematic Review.

Ciobotaru C, Festila D, Dinte E, Muntean A, Bosca B, Ionel A Pharmaceutics. 2024; 16(8).

PMID: 39204329 PMC: 11360669. DOI: 10.3390/pharmaceutics16080984.

Role of vitamin D for orthodontic tooth movement, external apical root resorption, and bone biomarker expression and remodeling: A systematic review.

Ferrillo M, Calafiore D, Lippi L, Agostini F, Migliario M, Invernizzi M Korean J Orthod. 2024; 54(1):26-47.

PMID: 38268460 PMC: 10811359. DOI: 10.4041/kjod23.064.

References

Long H, Pyakurel U, Wang Y, Liao L, Zhou Y, Lai W . Interventions for accelerating orthodontic tooth movement: a systematic review. Angle Orthod. 2012; 83(1):164-71. PMC: 8805534. DOI: 10.2319/031512-224.1. View

Davidovitch Z . Tooth movement. Crit Rev Oral Biol Med. 1991; 2(4):411-50. DOI: 10.1177/10454411910020040101. View

Nakornnoi T, Leethanakul C, Samruajbenjakun B . The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits. Korean J Orthod. 2019; 49(6):372-380. PMC: 6883214. DOI: 10.4041/kjod.2019.49.6.372. View

Chien P, Khan K, Siassakos D . Registration of systematic reviews: PROSPERO. BJOG. 2012; 119(8):903-5. DOI: 10.1111/j.1471-0528.2011.03242.x. View

Henneman S, von den Hoff J, Maltha J . Mechanobiology of tooth movement. Eur J Orthod. 2008; 30(3):299-306. DOI: 10.1093/ejo/cjn020. View

Yamasaki K, Miura F, Suda T . Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats. J Dent Res. 1980; 59(10):1635-42. DOI: 10.1177/00220345800590101301. View

Spielmann T, Wieslander L, Hefti A . [Acceleration of orthodontically induced tooth movement through the local application of prostaglandin (PGE1)]. Schweiz Monatsschr Zahnmed. 1989; 99(2):162-5. View

El-Timamy A, El Sharaby F, Eid F, El Dakroury A, Mostafa Y, Shaker O . Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Angle Orthod. 2020; 90(3):354-361. PMC: 8032296. DOI: 10.2319/072119-483.1. View

Otsuka E, Kato Y, Hirose S, Hagiwara H . Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology. 2000; 141(8):3006-11. DOI: 10.1210/endo.141.8.7597. View

10.

DREIZEN S, LEVY B, BERNICK S . Studies on the biology of the periodontium of marmosets. J Periodontal Res. 1969; 4(4):274-80. DOI: 10.1111/j.1600-0765.1969.tb01979.x. View

11.

Stewart D, Sherick P, Kramer S, Breining P . Use of relaxin in orthodontics. Ann N Y Acad Sci. 2005; 1041:379-87. DOI: 10.1196/annals.1282.058. View

12.

Boyle W, Simonet W, Lacey D . Osteoclast differentiation and activation. Nature. 2003; 423(6937):337-42. DOI: 10.1038/nature01658. View

13.

Meikle M . The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. Eur J Orthod. 2006; 28(3):221-40. DOI: 10.1093/ejo/cjl001. View

14.

Bumann A, Carvalho R, Schwarzer C, Yen E . Collagen synthesis from human PDL cells following orthodontic tooth movement. Eur J Orthod. 1997; 19(1):29-37. DOI: 10.1093/ejo/19.1.29. View

15.

Varughese S, Shamanna P, Goyal N, Thomas B, Lakshmanan L, Pulikkottil V . Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial. J Contemp Dent Pract. 2020; 20(12):1430-1435. View

16.

Litton S . Orthodontic tooth movement during an ascorbic acid deficiency. Am J Orthod. 1974; 65(3):290-302. DOI: 10.1016/s0002-9416(74)90333-9. View

17.

Yamasaki K, Shibata Y, Fukuhara T . The effect of prostaglandins on experimental tooth movement in monkeys (Macaca fuscata). J Dent Res. 1982; 61(12):1444-6. DOI: 10.1177/00220345820610121401. View

18.

Anitua E, Zalduendo M, Troya M, Padilla S, Orive G . Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties. PLoS One. 2015; 10(3):e0121713. PMC: 4379078. DOI: 10.1371/journal.pone.0121713. View

19.

Krishnan V, Davidovitch Z . Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop. 2006; 129(4):469.e1-32. DOI: 10.1016/j.ajodo.2005.10.007. View

20.

Guyatt G, Oxman A, Schunemann H, Tugwell P, Knottnerus A . GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2010; 64(4):380-2. DOI: 10.1016/j.jclinepi.2010.09.011. View