Amniotic Membrane Transplantation in a 2-month-old Infant with Toxic Epidermal Necrolysis

Overview

Journal Am J Ophthalmol Case Rep

Specialty Ophthalmology

Date 2021 Feb 1

PMID 33521381

Citations 1

Authors

Abdelrahman M Elhusseiny

Ryan Gise

Christina Scelfo

Iason S Mantagos

Affiliations

Soon will be listed here.

Abstract

Purpose: To report a case of 2-month-old boy with Stevens-Johnson syndrome (SJS)/Toxic epidermal necrolysis (TEN) and ocular involvement that was successfully treated with cryopreserved amniotic membrane transplantation (AMT).

Observation: A 2-month-old otherwise healthy boy was referred to Boston Children's Hospital with extensive rash and desquamation concerning for SJS/TEN. A skin biopsy was performed which showed full-thickness epidermal necrosis. AMT was performed at the bedside under general anesthesia. A combination of tobramycin and dexamethasone ointment was prescribed four times per day. On reassessment two weeks following AMT, the entire ocular surface had healed with no signs of conjunctival and/or corneal inflammation or ulceration.

Conclusion And Importance: To the best of our knowledge, our case represents the youngest patient with SJS/TEN to be managed by AMT and one of very few cases where acetaminophen is suspected to be the offending agent. This case highlights the efficacy of AMT at such a young age and feasibility of performing the procedure at bedside in these patients It also highlights that SJS/TEN can develop at such young age.

Citing Articles

Update on the application of amniotic membrane in immune-related ocular surface diseases.

Chen Z, Lao H, Liang L Taiwan J Ophthalmol. 2021; 11(2):132-140.

PMID: 34295618 PMC: 8259520. DOI: 10.4103/tjo.tjo_16_21.

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