Carbon Nanotube Modified Microelectrode Array for Neural Interface

Overview

Journal Front Bioeng Biotechnol

Date 2021 Feb 1

PMID 33520951

Citations 13

Authors

Mohaddeseh Vafaiee

Raheleh Mohammadpour

Manouchehr Vossoughi

Elham Asadian

Mahyar Janahmadi

Pezhman Sasanpour

Affiliations

Soon will be listed here.

Abstract

Carbon nanotubes (CNTs) coatings have been shown over the past few years as a promising material for neural interface applications. In particular, in the field of nerve implants, CNTs have fundamental advantages due to their unique mechanical and electrical properties. In this study, carbon nanotubes multi-electrode arrays (CNT-modified-Au MEAs) were fabricated based on gold multi-electrode arrays (Au-MEAs). The electrochemical impedance spectra of CNT-modified-Au MEA and Au-MEA were compared employing equivalent circuit models. In comparison with Au-MEA (17 Ω), CNT-modified-Au MEA (8 Ω) lowered the overall impedance of the electrode at 1 kHz by 50%. The results showed that CNT-modified-Au MEAs have good properties such as low impedance, high stability and durability, as well as scratch resistance, which makes them appropriate for long-term application in neural interfaces.

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References

Malarkey E, Parpura V . Applications of carbon nanotubes in neurobiology. Neurodegener Dis. 2007; 4(4):292-9. DOI: 10.1159/000101885. View

Dimaki M, Vergani M, Heiskanen A, Kwasny D, Sasso L, Carminati M . A compact microelectrode array chip with multiple measuring sites for electrochemical applications. Sensors (Basel). 2014; 14(6):9505-21. PMC: 4118406. DOI: 10.3390/s140609505. View

Randviir E, Banks C . A review of electrochemical impedance spectroscopy for bioanalytical sensors. Anal Methods. 2022; 14(45):4602-4624. DOI: 10.1039/d2ay00970f. View

Gross G . Simultaneous single unit recording in vitro with a photoetched laser deinsulated gold multimicroelectrode surface. IEEE Trans Biomed Eng. 1979; 26(5):273-9. DOI: 10.1109/tbme.1979.326402. View

Reza Abidian M, Corey J, Kipke D, Martin D . Conducting-polymer nanotubes improve electrical properties, mechanical adhesion, neural attachment, and neurite outgrowth of neural electrodes. Small. 2010; 6(3):421-9. PMC: 3045566. DOI: 10.1002/smll.200901868. View

Dhanasingh A, Jolly C . An overview of cochlear implant electrode array designs. Hear Res. 2017; 356:93-103. DOI: 10.1016/j.heares.2017.10.005. View

Park D, Schendel A, Mikael S, Brodnick S, Richner T, Ness J . Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nat Commun. 2014; 5:5258. PMC: 4218963. DOI: 10.1038/ncomms6258. View

Ghasemi-Mobarakeh L, Prabhakaran M, Morshed M, Nasr-Esfahani M, Baharvand H, Kiani S . Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. J Tissue Eng Regen Med. 2011; 5(4):e17-35. DOI: 10.1002/term.383. View

Senn P, Roccio M, Hahnewald S, Frick C, Kwiatkowska M, Ishikawa M . NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons. Otol Neurotol. 2017; 38(8):e224-e231. PMC: 5559190. DOI: 10.1097/MAO.0000000000001439. View

10.

Bottini M, Rosato N, Bottini N . PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromolecules. 2011; 12(10):3381-93. DOI: 10.1021/bm201020h. View

11.

Brummer S, Turner M . Electrochemical considerations for safe electrical stimulation of the nervous system with platinum electrodes. IEEE Trans Biomed Eng. 1977; 24(1):59-63. DOI: 10.1109/TBME.1977.326218. View

12.

Castagnola E, Maiolo L, Maggiolini E, Minotti A, Marrani M, Maita F . PEDOT-CNT-Coated Low-Impedance, Ultra-Flexible, and Brain-Conformable Micro-ECoG Arrays. IEEE Trans Neural Syst Rehabil Eng. 2014; 23(3):342-50. DOI: 10.1109/TNSRE.2014.2342880. View

13.

Myllymaa S, Myllymaa K, Korhonen H, Toyras J, Jaaskelainen J, Djupsund K . Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials. Biosens Bioelectron. 2009; 24(10):3067-72. DOI: 10.1016/j.bios.2009.03.028. View

14.

Cogan S . Neural stimulation and recording electrodes. Annu Rev Biomed Eng. 2008; 10:275-309. DOI: 10.1146/annurev.bioeng.10.061807.160518. View

15.

Ghasemi-Mobarakeh L, Prabhakaran M, Morshed M, Nasr-Esfahani M, Ramakrishna S . Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. Biomaterials. 2008; 29(34):4532-9. DOI: 10.1016/j.biomaterials.2008.08.007. View

16.

Grumet A, WYATT Jr J, Rizzo 3rd J . Multi-electrode stimulation and recording in the isolated retina. J Neurosci Methods. 2000; 101(1):31-42. DOI: 10.1016/s0165-0270(00)00246-6. View

17.

Xue N, Martinez I, Sun J, Cheng Y, Liu C . Flexible multichannel vagus nerve electrode for stimulation and recording for heart failure treatment. Biosens Bioelectron. 2018; 112:114-119. DOI: 10.1016/j.bios.2018.04.043. View

18.

Voge C, Stegemann J . Carbon nanotubes in neural interfacing applications. J Neural Eng. 2011; 8(1):011001. DOI: 10.1088/1741-2560/8/1/011001. View

19.

Butson C, McIntyre C . Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation. Clin Neurophysiol. 2005; 116(10):2490-500. PMC: 3653320. DOI: 10.1016/j.clinph.2005.06.023. View

20.

Bekyarova E, Ni Y, Malarkey E, Montana V, McWilliams J, Haddon R . Applications of Carbon Nanotubes in Biotechnology and Biomedicine. J Biomed Nanotechnol. 2009; 1(1):3-17. PMC: 2745127. DOI: 10.1166/jbn.2005.004. View