OCT-OCTA Segmentation: Combining Structural and Blood Flow Information to Segment Bruch's Membrane

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2021 Feb 1

PMID 33520378

Citations 8

Authors

Julia Schottenhamml

Eric M Moult

Stefan B Ploner

Siyu Chen

Eduardo Novais

Lennart Husvogt

Jay S Duker

Nadia K Waheed

James G Fujimoto

Andreas K Maier

Affiliations

Soon will be listed here.

Abstract

In this paper we present a fully automated graph-based segmentation algorithm that jointly uses optical coherence tomography (OCT) and OCT angiography (OCTA) data to segment Bruch's membrane (BM). This is especially valuable in cases where the spatial correlation between BM, which is usually not visible on OCT scans, and the retinal pigment epithelium (RPE), which is often used as a surrogate for segmenting BM, is distorted by pathology. We validated the performance of our proposed algorithm against manual segmentation in a total of 18 eyes from healthy controls and patients with diabetic retinopathy (DR), non-exudative age-related macular degeneration (AMD) (early/intermediate AMD, nascent geographic atrophy (nGA) and drusen-associated geographic atrophy (DAGA) and geographic atrophy (GA)), and choroidal neovascularization (CNV) with a mean absolute error of ∼0.91 pixel (∼4.1 μm). This paper suggests that OCT-OCTA segmentation may be a useful framework to complement the growing usage of OCTA in ophthalmic research and clinical communities.

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