Importance of Extracellular Vesicles in Hypertension

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2021 Feb 1

PMID 33517775

Citations 11

Authors

Zhi Z Liu

Pedro A Jose

Jian Yang

Chunyu Zeng

Affiliations

Soon will be listed here.

Abstract

Hypertension affects approximately 1.13 billion adults worldwide and is the leading global risk factor for cardiovascular, cerebrovascular, and kidney diseases. There is emerging evidence that extracellular vesicles participate in the development and progression of hypertension. Extracellular vesicles are membrane-enclosed structures released from nearly all types of eukaryotic cells. During their formation, extracellular vesicles incorporate various parent cell components, including proteins, lipids, and nucleic acids that can be transferred to recipient cells. Extracellular vesicles mediate cell-to-cell communication in a variety of physiological and pathophysiological processes. Therefore, studying the role of circulating and urinary extracellular vesicles in hypertension has the potential to identify novel noninvasive biomarkers and therapeutic targets of different hypertension phenotypes. This review discusses the classification and biogenesis of three EV subcategories (exosomes, microvesicles, and apoptotic bodies) and provides a summary of recent discoveries in the potential impact of extracellular vesicles on hypertension with a specific focus on their role in the blood pressure regulation by organs-artery and kidney, as well as renin-angiotensin-system.

Citing Articles

Investigation of Antihypertensive Properties of Chios Mastic via Monitoring microRNA-21 Expression Levels in the Plasma of Well-Controlled Hypertensive Patients.

Tsota M, Giardoglou P, Mentsiou-Nikolaou E, Symianakis P, Kalafati I, Kyriazopoulou-Korovesi A Noncoding RNA. 2024; 10(3).

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The Proteome of Extracellular Vesicles Released from Pulmonary Microvascular Endothelium Reveals Impact of Oxygen Conditions on Biotrauma.

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Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup.

Byappanahalli A, Omoniyi V, Noren Hooten N, Smith J, Mode N, Ezike N iScience. 2024; 27(1):108724.

PMID: 38226163 PMC: 10788249. DOI: 10.1016/j.isci.2023.108724.

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery.

Al-Jipouri A, Eritja A, Bozic M Int J Mol Sci. 2024; 25(1).

PMID: 38203656 PMC: 10779093. DOI: 10.3390/ijms25010485.

Extracellular Vesicles and Hypertension.

Tang H, Hu Y, Deng J Adv Exp Med Biol. 2023; 1418:69-80.

PMID: 37603273 DOI: 10.1007/978-981-99-1443-2_5.

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