Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Overview

Journal Tissue Eng Regen Med

Date 2021 Jan 29

PMID 33511556

Citations 13

Authors

Donggang Mou

Qunying Yu

Jimei Zhang

Jianping Zhou

Xinmin Li

Weiyi Zhuang

Xuming Yang

Affiliations

Soon will be listed here.

Abstract

Background: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of long-term maintenance of efficacy.

Methods: In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N-carboxyethyl chitosan (N-chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid-aldehyde (HA-ALD).

Results: This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-α, IL-1β, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection.

Conclusion: This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.

Citing Articles

Long-Term Efficacy of Carboxymethyl-Chitosan in Advanced Knee Osteoarthritis: A Twelve-Month Follow-Up Study on Non-Responders to Hyaluronic Acid.

Manocchio N, Pirri C, Ljoka C, Sorbino A, Piacentini N, Monello C Biomedicines. 2025; 13(2).

PMID: 40002684 PMC: 11852378. DOI: 10.3390/biomedicines13020270.

Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review.

Kang Y, Guan Y, Li S Int J Surg. 2024; 110(12):7984-8001.

PMID: 39236090 PMC: 11634198. DOI: 10.1097/JS9.0000000000002076.

Functional biomaterials for osteoarthritis treatment: From research to application.

Lei Y, Zhang Q, Kuang G, Wang X, Fan Q, Ye F Smart Med. 2024; 1(1):e20220014.

PMID: 39188730 PMC: 11235767. DOI: 10.1002/SMMD.20220014.

Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy.

DeMoya C, Joenathan A, Lawson T, Felson D, Schaer T, Bais M Nat Rev Rheumatol. 2024; 20(7):432-451.

PMID: 38858605 PMC: 11348290. DOI: 10.1038/s41584-024-01125-5.

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations.

Kruczkowska W, Galeziewska J, Grabowska K, Liese G, Buczek P, Klosinski K Gels. 2024; 10(5).

PMID: 38786212 PMC: 11121652. DOI: 10.3390/gels10050295.

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