Sporadic Parkinson's Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2021 Jan 29

PMID 33510632

Citations 4

Authors

Bo Wang

Xin Liu

Shengyuan Xu

Zheng Liu

Yu Zhu

Xiong Zhang

Renshi Xu

Affiliations

Soon will be listed here.

Abstract

Recent investigations demonstrated that genetic factors might play an important role in sporadic Parkinson's disease (sPD). To clarify the specific loci susceptibility to sPD, we analyze the relationship between 30 candidate single nucleotide polymorphisms (SNPs) and sPD in the population of Han ancestry from Chinese mainland (HACM) by using genome-wide association study, sequenom massARRAY, DNA sequence, and biological information analysis. Results showed that the subjects carrying the T allele of rs863108 and rs28499371 exhibited a decreased risk for sPD. The subjects carrying the T allele of rs80315856 exhibited an increased risk for sPD. The A/T genotype of rs863108 and the C/T genotype of rs28499371 were a potential increased risk for sPD, and the G/T genotype of rs80315856 and T/T genotype of rs2270568 were a potential decreased risk for sPD. The minor allele frequency (MAF) of rs80315856 and rs2270568 was higher in sPD. The T allele of rs80315856 and rs2270568 might be a risk locus for sPD. Our data suggested that the alteration of these SNPs might play some roles through changing/affecting LINC01524/LOC105372666, DMRT2/SMARCA2, PLEKHN1, and FLJ23172/FNDC3B genes in the pathogenesis of sPD.

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References

Fagerberg L, Hallstrom B, Oksvold P, Kampf C, Djureinovic D, Odeberg J . Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 2013; 13(2):397-406. PMC: 3916642. DOI: 10.1074/mcp.M113.035600. View

Hellquist A, Zucchelli M, Lindgren C, Saarialho-Kere U, Jarvinen T, Koskenmies S . Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). PLoS One. 2009; 4(12):e8037. PMC: 2785483. DOI: 10.1371/journal.pone.0008037. View

Sano E, Shono S, Tashiro K, Konishi H, Yamauchi E, Taniguchi H . Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. Biochim Biophys Acta. 2008; 1783(6):1036-47. DOI: 10.1016/j.bbamcr.2007.12.009. View

Rozenkrantz L, Gan-Or Z, Gana-Weisz M, Mirelman A, Giladi N, Bar-Shira A . SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain. J Mol Neurosci. 2016; 59(3):343-50. DOI: 10.1007/s12031-016-0738-3. View

Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G . Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim Biophys Acta. 2016; 1861(11):1816-1827. DOI: 10.1016/j.bbalip.2016.09.006. View

Soldner F, Stelzer Y, Shivalila C, Abraham B, Latourelle J, Barrasa M . Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature. 2016; 533(7601):95-9. PMC: 5042324. DOI: 10.1038/nature17939. View

Jomova K, Vondrakova D, Lawson M, Valko M . Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem. 2010; 345(1-2):91-104. DOI: 10.1007/s11010-010-0563-x. View

Ottolenghi C, Veitia R, Barbieri M, Fellous M, McElreavey K . The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript. Genomics. 2000; 64(2):179-86. DOI: 10.1006/geno.2000.6120. View

Maeda A, Uchida M, Nishikawa S, Nishino T, Konishi H . Role of N-myristoylation in stability and subcellular localization of the CLPABP protein. Biochem Biophys Res Commun. 2017; 495(1):1249-1256. DOI: 10.1016/j.bbrc.2017.11.112. View

10.

Yang X, Zhao Q, An R, Zhou H, Lin Z, Xu Y . SNP rs1805874 of the Calbindin1 Gene Is Associated with Parkinson's Disease in Han Chinese. Genet Test Mol Biomarkers. 2016; 20(12):753-757. DOI: 10.1089/gtmb.2016.0149. View

11.

Xu Y, Zhang J, Chen X . The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. J Biol Chem. 2007; 282(52):37429-35. DOI: 10.1074/jbc.M706039200. View

12.

Lango Allen H, Estrada K, Lettre G, Berndt S, Weedon M, Rivadeneira F . Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010; 467(7317):832-8. PMC: 2955183. DOI: 10.1038/nature09410. View

13.

Garrido-Urbani S, Garg P, Ghossoub R, Arnold R, Lembo F, Sundell G . Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin. FEBS Lett. 2016; 590(1):3-12. PMC: 4819696. DOI: 10.1002/1873-3468.12037. View

14.

Wang L, Maldonado L, Beecham G, Martin E, Evatt M, Ritchie J . DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient. Neurol Genet. 2016; 2(3):e72. PMC: 4830205. DOI: 10.1212/NXG.0000000000000072. View

15.

Kowenz-Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A . Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010; 29(6):1105-15. PMC: 2845275. DOI: 10.1038/emboj.2010.3. View

16.

Fahn S . Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci. 2003; 991:1-14. DOI: 10.1111/j.1749-6632.2003.tb07458.x. View

17.

Li J, Jin M, Wang L, Qin B, Wang K . MDS clinical diagnostic criteria for Parkinson's disease in China. J Neurol. 2016; 264(3):476-481. DOI: 10.1007/s00415-016-8370-2. View

18.

Snyder B, Duong P, Trieu J, Cunningham R . Androgens modulate chronic intermittent hypoxia effects on brain and behavior. Horm Behav. 2018; 106:62-73. PMC: 6486829. DOI: 10.1016/j.yhbeh.2018.09.005. View

19.

Marsden C . Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994; 57(6):672-81. PMC: 1072968. DOI: 10.1136/jnnp.57.6.672. View

20.

Kalia L, Lang A . Parkinson's disease. Lancet. 2015; 386(9996):896-912. DOI: 10.1016/S0140-6736(14)61393-3. View