Oligodendrocyte Precursor Cell Specification is Regulated by Bidirectional Neural Progenitor-endothelial Cell Crosstalk

Overview

Journal Nat Neurosci

Date 2021 Jan 29

PMID 33510480

Citations 13

Authors

Isidora Paredes

Jose Ricardo Vieira

Bhavin Shah

Carla F Ramunno

Julia Dyckow

Heike Adler

Melanie Richter

Geza Schermann

Evangelia Giannakouri

Lucas Schirmer

Hellmut G Augustin

Carmen Ruiz de Almodovar

Affiliations

Soon will be listed here.

Abstract

Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification. Mechanistically, we show that neural progenitor cells (NPCs) express angiopoietin-1 (Ang1) and that this expression is regulated by Sonic hedgehog. We demonstrate that NPC-derived Ang1 signals to its receptor, Tie2, on endothelial cells to induce the production of transforming growth factor beta 1 (TGFβ1). Endothelial-derived TGFβ1, in turn, acts as an angiocrine molecule and signals back to NPCs to induce their commitment toward oligodendrocyte precursor cells. This work demonstrates a true bidirectional collaboration between NPCs and the vasculature as a critical regulator of oligodendrogenesis.

Citing Articles

Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development.

Wang W, Wang Y, Su L, Zhang M, Zhang T, Zhao J Adv Sci (Weinh). 2024; 11(38):e2308508.

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Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS.

Nguyen L, Aprico A, Nwoke E, Walsh A, Blades F, Avneri R J Neuroinflammation. 2023; 20(1):253.

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Endothelial-derived angiocrine factors as instructors of embryonic development.

Bishop D, Schwarz Q, Wiszniak S Front Cell Dev Biol. 2023; 11:1172114.

PMID: 37457293 PMC: 10339107. DOI: 10.3389/fcell.2023.1172114.

Oligodendrocyte precursor cells: the multitaskers in the brain.

Fang L, Bai X Pflugers Arch. 2023; 475(9):1035-1044.

PMID: 37401986 PMC: 10409806. DOI: 10.1007/s00424-023-02837-5.

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.

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