Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis

Overview

Journal Obes Facts

Publisher Karger

Specialty Endocrinology

Date 2021 Jan 28

PMID 33508842

Citations 4

Authors

Laurent Irakoze

Astere Manirakiza

Yunqi Zhang

Juncheng Liu

Jiayu Li

Liliane Nkengurutse

Shuhua Deng

Xiaoqiu Xiao

Affiliations

Soon will be listed here.

Abstract

Background: The metabolic syndrome (MetS) represents a clustering of risk factors for cardiovascular diseases that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance.

Objectives: The objective of this study was to reassess the parent-offspring association of MetS since the available findings are still controversial.

Methods: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All studies comparing MetS status between the offspring of parents with MetS and offspring of parents without MetS were included in the analysis.

Results: A total of 9 studies met the inclusion criteria and they were analyzed. Offspring of at least 1 parent with MetS had a higher risk of MetS (OR 3.88, 95% CI 2.58-5.83, p < 0.001). Sons and daughters of fathers with MetS both had a higher risk of MetS (OR 2.31, 95% CI 1.70-3.12, p < 0.001, and OR 1.73, 95% CI 1.37-2.18, p < 0.001, respectively). Sons and daughters of mothers with MetS both had a higher risk of MetS (OR 1.95, 95% CI 1.37-2.76, p = 0.0002, and OR 1.91, 95% CI 1.54-2.35, p < 0.001, respectively).

Conclusion: This meta-analysis showed that there is a higher risk of MetS in the offspring of parents with MetS. However, there was no differential association of MetS according to gender and/or age of the offspring.

Citing Articles

The Beneficial Effects of Prenatal Biotin Supplementation in a Rat Model of Intrauterine Caloric Restriction to Prevent Cardiometabolic Risk in Adult Female Offspring.

Aguilera-Mendez A, Figueroa-Fierros I, Ruiz-Perez X, Godinez-Hernandez D, Saavedra-Molina A, Rios-Chavez P Int J Mol Sci. 2024; 25(16).

PMID: 39201737 PMC: 11354830. DOI: 10.3390/ijms25169052.

Parent-Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey.

Hoang M, Jung S, Lee H, Kim H J Am Heart Assoc. 2024; 13(2):e030995.

PMID: 38214252 PMC: 10926814. DOI: 10.1161/JAHA.123.030995.

Parental metabolic syndrome and elevated liver transaminases are risk factors for offspring, even in children and adolescents with a normal body mass index.

Song K, Yang J, Lee H, Oh J, Kim S, Lee M Front Nutr. 2023; 10:1166244.

PMID: 37941769 PMC: 10627857. DOI: 10.3389/fnut.2023.1166244.

Quality of life and psychosocial outcomes among children with metabolically healthy and unhealthy obesity.

Ooi D, Ong S, Chia J, Lim Y, Ho C, Tay V Pediatr Res. 2023; 94(3):1089-1097.

PMID: 36949286 DOI: 10.1038/s41390-023-02572-8.

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