Analysis of Curcumin As a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control Trial

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2021 Jan 28

PMID 33507691

Citations 9

Authors

Yudi Mulyana Hidayat

Frank Wagey

Dodi Suardi

Herman Susanto

Bismarck J Laihad

Maringan Diapari Lumban Tobing

Affiliations

Soon will be listed here.

Abstract

Objective: One of the important treatments for cervical cancer is radiation therapy. This study sought to determine the role of curcumin as a radio-sensitizing agent for use with radiation therapy for cervical cancer. To accomplish this, we assessed the levels of survivin, which is an anti-apoptotic protein that plays a role in cell division and apoptosis inhibition.

Method: This study used a quasi-experimental design, including a pretest-posttest control group design approach. The study subjects included cervical carcinoma stage IIB-IIIB patients who were scheduled to undergo surgery at the Hasan Sadikin Hospital Bandung during the research period. The advanced cervical cancer patients were assigned to two groups: i) those who received curcumin + radiation therapy and ii) those who received placebo + radiation therapy.

Results: In the group treated with curcumin + radiation, 15 (75%) patients showed decreased survivin levels and 5 (25%) showed increased survivin levels. Whereas, in the placebo + radiation group, there were 8 (40%) patients who showed decreased survivin levels and 12 (60%) who showed increased survivin levels.

Conclusion: In conclusion, curcumin is an effective, alternative radiosensitizer agent for application in cervical cancer treatment.<br />.

Citing Articles

Nature's weapons: Bioactive compounds as anti-cancer agents.

Auti A, Tathode M, Marino M, Vitiello A, Ballini A, Miele F AIMS Public Health. 2024; 11(3):747-772.

PMID: 39416904 PMC: 11474324. DOI: 10.3934/publichealth.2024038.

Anti-Cancer Properties of Two Intravenously Administrable Curcumin Formulations as Evaluated in the 3D Patient-Derived Cancer Spheroid Model.

Niederreiter M, Klein J, Schmitz S, Werner J, Mayer B Int J Mol Sci. 2024; 25(15).

PMID: 39126111 PMC: 11313667. DOI: 10.3390/ijms25158543.

Curcumin in Cancer Prevention: Insights from Clinical Trials and Strategies to Enhance Bioavailability.

Alam S, Lee J, Sahebkar A Curr Pharm Des. 2024; 30(23):1838-1851.

PMID: 38808709 DOI: 10.2174/0113816128303514240517054617.

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials.

Kunnumakkara A, Hegde M, Parama D, Girisa S, Kumar A, Daimary U ACS Pharmacol Transl Sci. 2023; 6(4):447-518.

PMID: 37082752 PMC: 10111629. DOI: 10.1021/acsptsci.2c00012.

Natural biomolecules and derivatives as anticancer immunomodulatory agents.

Bernitsa S, Dayan R, Stephanou A, Tzvetanova I, Patrikios I Front Immunol. 2023; 13:1070367.

PMID: 36700235 PMC: 9868674. DOI: 10.3389/fimmu.2022.1070367.

References

Rodel F, Reichert S, Sprenger T, Gaipl U, Mirsch J, Liersch T . The role of survivin for radiation oncology: moving beyond apoptosis inhibition. Curr Med Chem. 2010; 18(2):191-9. DOI: 10.2174/092986711794088362. View

Miller A, Hoogstraten B, STAQUET M, Winkler A . Reporting results of cancer treatment. Cancer. 1981; 47(1):207-14. DOI: 10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6. View

Rodel F, Hoffmann J, Distel L, Herrmann M, Noisternig T, Papadopoulos T . Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res. 2005; 65(11):4881-7. DOI: 10.1158/0008-5472.CAN-04-3028. View

Rodel C, Haas J, Groth A, Grabenbauer G, Sauer R, Rodel F . Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor. Int J Radiat Oncol Biol Phys. 2003; 55(5):1341-7. DOI: 10.1016/s0360-3016(02)04618-7. View

Siegel R, Naishadham D, Jemal A . Cancer statistics, 2012. CA Cancer J Clin. 2012; 62(1):10-29. DOI: 10.3322/caac.20138. View

Borek C . Antioxidants and radiation therapy. J Nutr. 2004; 134(11):3207S-3209S. DOI: 10.1093/jn/134.11.3207S. View

Shepherd L, Bryson S . Human papillomavirus--lessons from history and challenges for the future. J Obstet Gynaecol Can. 2009; 30(11):1025-1033. DOI: 10.1016/S1701-2163(16)32997-8. View

Gall Troselj K, Novak Kujundzic R . Curcumin in combined cancer therapy. Curr Pharm Des. 2014; 20(42):6682-96. DOI: 10.2174/1381612820666140826154601. View

Weir N, Selvendiran K, Kutala V, Tong L, Vishwanath S, Rajaram M . Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther. 2007; 6(2):178-84. PMC: 1852522. DOI: 10.4161/cbt.6.2.3577. View

10.

Palfalvi L, Ungar L . Laterally extended parametrectomy (LEP), the technique for radical pelvic side wall dissection: Feasibility, technique and results. Int J Gynecol Cancer. 2003; 13(6):914-7. DOI: 10.1111/j.1525-1438.2003.13043.x. View

11.

Ambrosini G, Adida C, Altieri D . A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997; 3(8):917-21. DOI: 10.1038/nm0897-917. View

12.

Chalian H, Tore H, Horowitz J, Salem R, Miller F, Yaghmai V . Radiologic assessment of response to therapy: comparison of RECIST Versions 1.1 and 1.0. Radiographics. 2011; 31(7):2093-105. DOI: 10.1148/rg.317115050. View

13.

Hu S, Xu Y, Meng L, Huang L, Sun H . Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med. 2018; 16(2):1266-1272. PMC: 6090267. DOI: 10.3892/etm.2018.6345. View

14.

Menon C, Fraker D . Tumor oxygenation status as a prognostic marker. Cancer Lett. 2005; 221(2):225-35. DOI: 10.1016/j.canlet.2004.06.029. View

15.

Park J, Conteas C . Anti-carcinogenic properties of curcumin on colorectal cancer. World J Gastrointest Oncol. 2010; 2(4):169-76. PMC: 2999181. DOI: 10.4251/wjgo.v2.i4.169. View

16.

Banik U, Parasuraman S, Adhikary A, Othman N . Curcumin: the spicy modulator of breast carcinogenesis. J Exp Clin Cancer Res. 2017; 36(1):98. PMC: 5517797. DOI: 10.1186/s13046-017-0566-5. View

17.

Wang X, Jiang Y, Wang Y, Huang M, Ho C, Huang Q . Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2015; 108(2):419-24. DOI: 10.1016/j.foodchem.2007.10.086. View

18.

Candelaria M, Garcia-Arias A, Cetina L, Duenas-Gonzalez A . Radiosensitizers in cervical cancer. Cisplatin and beyond. Radiat Oncol. 2006; 1:15. PMC: 1479830. DOI: 10.1186/1748-717X-1-15. View

19.

Schopfer P, Plachy C, Frahry G . Release of reactive oxygen intermediates (superoxide radicals, hydrogen peroxide, and hydroxyl radicals) and peroxidase in germinating radish seeds controlled by light, gibberellin, and abscisic acid. Plant Physiol. 2001; 125(4):1591-602. PMC: 88817. DOI: 10.1104/pp.125.4.1591. View

20.

Chen H, Zhang Z, Zhang Y, Zhou D . Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res. 2000; 19(5A):3675-80. View