Highlight Selection of Radiochemistry and Radiopharmacy Developments by Editorial Board (January-June 2020)

Overview

Journal EJNMMI Radiopharm Chem

Date 2021 Jan 28

PMID 33507426

Authors

Mohammed Al-Qahtani

Martin Behe

Guy Bormans

Giuseppe Carlucci

Jean DaSilva

Clemens Decristoforo

Philip H Elsinga

Klaus Kopka

Xiang-Guo Li

Robert Mach

Oskar Middel

Jan Passchier

Marianne Patt

Ivan Penuelas

Ana Rey

Peter J H Scott

Sergio Todde

Jun Toyohara

Danielle Vugts

Affiliations

Soon will be listed here.

Abstract

Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to describe trends in the field.

Results: This commentary of highlights has resulted in 19 different topics selected by each member of the Editorial Board addressing a variety of aspects ranging from novel radiochemistry to first in man application of novel radiopharmaceuticals.

Conclusion: Trends in radiochemistry and radiopharmacy are highlighted demonstrating the progress in the research field being the scope of EJNMMI Radiopharmacy and Chemistry.

References

Verweij N, Yaqub M, Bruijnen S, Pieplenbosch S, Ter Wee M, Jansen G . First in man study of [F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis. Sci Rep. 2020; 10(1):1047. PMC: 6978456. DOI: 10.1038/s41598-020-57841-x. View

Kjaergaard K, Sandahl T, Frisch K, Vase K, Keiding S, Vilstrup H . Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [Cu]copper PET/CT. EJNMMI Radiopharm Chem. 2020; 5(1):15. PMC: 7303253. DOI: 10.1186/s41181-020-00100-1. View

Laverman P, McBride W, Sharkey R, Eek A, Joosten L, Oyen W . A novel facile method of labeling octreotide with (18)F-fluorine. J Nucl Med. 2010; 51(3):454-61. PMC: 2908260. DOI: 10.2967/jnumed.109.066902. View

Zhao X, Lv G, Li K, Peng Y, Liu Q, Qiu L . One-step F-fluorination of smart positron emission tomography tracer for sensing furin activity in tumors. Nucl Med Biol. 2020; 82-83:72-79. DOI: 10.1016/j.nucmedbio.2020.02.010. View

Kee C, Tack O, Guibbal F, Wilson T, Isenegger P, Imiolek M . F-Trifluoromethanesulfinate Enables Direct C-H F-Trifluoromethylation of Native Aromatic Residues in Peptides. J Am Chem Soc. 2020; 142(3):1180-1185. PMC: 6978814. DOI: 10.1021/jacs.9b11709. View

Tshibangu T, Cawthorne C, Serdons K, Pauwels E, Gsell W, Bormans G . Automated GMP compliant production of [F]AlF-NOTA-octreotide. EJNMMI Radiopharm Chem. 2020; 5(1):4. PMC: 6989705. DOI: 10.1186/s41181-019-0084-1. View

Eriksson J, Antoni G, Langstrom B, Itsenko O . The development of C-carbonylation chemistry: A systematic view. Nucl Med Biol. 2020; 92:115-137. DOI: 10.1016/j.nucmedbio.2020.02.005. View

Laverman P, DSouza C, Eek A, McBride W, Sharkey R, Oyen W . Optimized labeling of NOTA-conjugated octreotide with F-18. Tumour Biol. 2011; 33(2):427-34. PMC: 3296034. DOI: 10.1007/s13277-011-0250-x. View

Hensbergen A, Buckle T, van Willigen D, Schottelius M, Welling M, van der Wijk F . Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction. J Nucl Med. 2019; 61(2):234-241. PMC: 8801960. DOI: 10.2967/jnumed.119.233064. View

10.

Lindner T, Altmann A, Kramer S, Kleist C, Loktev A, Kratochwil C . Design and Development of Tc-Labeled FAPI Tracers for SPECT Imaging and Re Therapy. J Nucl Med. 2020; 61(10):1507-1513. PMC: 7539653. DOI: 10.2967/jnumed.119.239731. View

11.

Chiotellis A, Ahmed H, Betzel T, Tanriver M, White C, Song H . Chemoselective F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature. Chem Commun (Camb). 2019; 56(5):723-726. DOI: 10.1039/c9cc08645e. View

12.

Steen E, Jorgensen J, Johann K, Norregaard K, Sohr B, Svatunek D . -Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging. ACS Nano. 2019; 14(1):568-584. PMC: 7075664. DOI: 10.1021/acsnano.9b06905. View

13.

Lisova K, Sergeev M, Evans-Axelsson S, Stuparu A, Beykan S, Collins J . Microscale radiosynthesis, preclinical imaging and dosimetry study of [F]AMBF-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol. 2018; 61:36-44. PMC: 6015542. DOI: 10.1016/j.nucmedbio.2018.04.001. View

14.

Cullinane C, Waldeck K, Kirby L, Rogers B, Eu P, Tothill R . Enhancing the anti-tumour activity of Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP. Sci Rep. 2020; 10(1):10196. PMC: 7311440. DOI: 10.1038/s41598-020-67199-9. View

15.

Mayer A, Gambhir S . The Immunoimaging Toolbox. J Nucl Med. 2018; 59(8):1174-1182. PMC: 6071502. DOI: 10.2967/jnumed.116.185967. View

16.

Toyonaga T, Smith L, Finnema S, Gallezot J, Naganawa M, Bini J . In Vivo Synaptic Density Imaging with C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease. J Nucl Med. 2019; 60(12):1780-1786. PMC: 6894376. DOI: 10.2967/jnumed.118.223867. View

17.

Wierstra P, Sandker G, Aarntzen E, Gotthardt M, Adema G, Bussink J . Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer. EJNMMI Radiopharm Chem. 2019; 4(1):29. PMC: 6834817. DOI: 10.1186/s41181-019-0078-z. View

18.

Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T . Visualization of AMPA receptors in living human brain with positron emission tomography. Nat Med. 2020; 26(2):281-288. DOI: 10.1038/s41591-019-0723-9. View

19.

Inkster J, Akurathi V, Sromek A, Chen Y, Neumeyer J, Packard A . A non-anhydrous, minimally basic protocol for the simplification of nucleophilic F-fluorination chemistry. Sci Rep. 2020; 10(1):6818. PMC: 7176689. DOI: 10.1038/s41598-020-61845-y. View

20.

Lisova K, Chen B, Wang J, Fong K, Clark P, van Dam R . Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[F]fluoroethyl)-L-tyrosine ([F]FET). EJNMMI Radiopharm Chem. 2020; 5(1):1. PMC: 6938530. DOI: 10.1186/s41181-019-0082-3. View