Phytochemical Analysis and Cholinesterase Inhibitory and Antioxidant Activities of Relevant in the Management of Alzheimer's Disease

Overview

Journal Int J Food Sci

Publisher Wiley

Date 2021 Jan 28

PMID 33506005

Citations 10

Authors

Simin Shabnam Lopa

Md Yusuf Al-Amin

Md Kamrul Hasan

Md Salim Ahammed

Km Monirul Islam

A H M Khurshid Alam

Toshihisa Tanaka

Md Golam Sadik

Affiliations

Soon will be listed here.

Abstract

, a popular vegetable in Bangladesh, is used in folk medicine to treat diseases of the nervous system. The objective of this study was to investigate the phytochemical profile and cholinesterase inhibitory and antioxidant potential of the extracts of . . Among the four tested extracts, the chloroform extract was found to exert the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with the IC (concentration required for 50% inhibition) values of 83.90 g/mL and 48.14 g/mL, respectively. Likewise, the chloroform extract showed the highest radical scavenging activity and reducing power. In DPPH radical scavenging assay, the IC value was found to be 113.27 g/mL, and in reducing power assay, the absorbance was found to be 1.916 at a concentration of 50 g/mL. Phytochemical analyses revealed that the chloroform extract contained 19.16 mg gallic acid equivalent (GAE)/g extract of phenolics and 41.84 mg catechin equivalent (CE)/g extract of flavonoids, which appeared to be the highest among the extracts. A significant correlation was observed between phenolic content and butyrylcholinesterase inhibition and antioxidant activity, while a moderate correlation was seen between flavonoid content and cholinesterase inhibition and antioxidant activity. These findings suggest that . is a natural source of cholinesterase inhibitors and antioxidants, which could be utilized as functional foods for Alzheimer's disease management.

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