Prospects for the Therapeutic Development of Umbilical Cord Blood-derived Mesenchymal Stem Cells

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2021 Jan 28

PMID 33505598

Citations 18

Authors

Soyoun Um

Jueun Ha

Soo Jin Choi

Wonil Oh

Hye Jin Jin

Affiliations

Soon will be listed here.

Abstract

Umbilical cord blood (UCB) is a primitive and abundant source of mesenchymal stem cells (MSCs). UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders. Despite the high latent self-renewal and differentiation capacity of these cells, the safety, efficacy, and yield of MSCs expanded for clinical applications remains a concern. However, immunomodulatory effects have emerged in various disease models, exhibiting specific mechanisms of action, such as cell migration and homing, angiogenesis, anti-apoptosis, proliferation, anti-cancer, anti-fibrosis, anti-inflammation and tissue regeneration. Herein, we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.

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