Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 28

PMID 33503876

Citations 6

Authors

Vincenzo De Falco

Stefania Napolitano

Daniela Esposito

Luigi Pio Guerrera

Davide Ciardiello

Luigi Formisano

Teresa Troiani

Affiliations

Soon will be listed here.

Abstract

Cutaneous melanoma is considered a rare tumor, although it is one of the most common cancers in young adults and its incidence has risen in the last decades. Targeted therapy, with BRAF and MEK inhibitors, and immunotherapy revolutionized the treatment of metastatic melanoma but there is still a considerable percentage of patients with primary or acquired resistance to these therapies. Recently, oncology researchers directed their attention at the role of long non-coding RNAs (lncRNAs) in different types of cancers, including melanoma. lncRNAs are RNA transcripts, initially considered "junk sequences", that have been proven to have a crucial role in the fine regulation of physiological and pathological processes of different tissues. Furthermore, they are more expressed in tumors than protein-coding genes, constituting perfect candidates either as biomarkers (diagnostic, prognostic, predictive) or as therapeutic targets. In this work, we reviewed all the literature available for lncRNA in melanoma, elucidating all the potential roles in this tumor.

Citing Articles

Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis.

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BRAF Mutations in Melanoma: Biological Aspects, Therapeutic Implications, and Circulating Biomarkers.

Castellani G, Buccarelli M, Arasi M, Rossi S, Pisanu M, Bellenghi M Cancers (Basel). 2023; 15(16).

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Pathogenic roles of long noncoding RNAs in melanoma: Implications in diagnosis and therapies.

Xiao Y, Xia Y, Wang Y, Xue C Genes Dis. 2023; 10(1):113-125.

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A novel risk model based on cuproptosis-related lncRNAs predicted prognosis and indicated immune microenvironment landscape of patients with cutaneous melanoma.

Zhou Y, Shu Q, Fu Z, Wang C, Gu J, Li J Front Genet. 2022; 13:959456.

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