Sugar- and Artificially-sweetened Beverages and the Risks of Chronic Kidney Disease: a Systematic Review and Dose-response Meta-analysis

Overview

Journal J Nephrol

Publisher Springer

Specialty Nephrology

Date 2021 Jan 27

PMID 33502726

Citations 6

Authors

Wei-Cheng Lo

Shih-Hsiang Ou

Chu-Lin Chou

Jin-Shuen Chen

Mei-Yi Wu

Mai-Szu Wu

Affiliations

Soon will be listed here.

Abstract

Background: Consumption of sugar or artificially-sweetened beverages (SASBs) has been linked to albuminuria, decline in kidney function, and risk of chronic kidney disease (CKD). However, the results are controversial. We therefore aim to evaluate the effects of sugar or artificially-sweetened beverage consumption on CKD risk.

Methods: Original observational studies reporting relative risks (RRs) with 95% confidence intervals (CIs) for the association between sugar or artificially-sweetened beverage consumption and impaired renal function or CKD risk in adults were identified using a systematic search of PubMed and EMBASE from inception to 20 February, 2019. Random effects model was applied to derive summary RRs and 95% CIs. Linear and non-linear dose-response relationships were estimated using data from sugar or artificially-sweetened beverage consumption categories in each study.

Results: The summary RR of CKD for high versus low sugar-sweetened beverage consumption was 1.30 (95% CI 0.88-1.94) according to six included studies with a total of 25,455 participants, while the pooled RR of CKD for high versus low artificially sweetened beverage consumption was 1.40 (95% CI 0.65-3.02) according to three studies with a total of 19,995 participants. For dose-response analysis, a significant, increased risk of CKD was observed with the sugar or artificially-sweetened beverage consumption above seven servings per week (P < 0.001).

Conclusion: Our study found a positive association between consumption of sugar or artificially-sweetened beverage consumption and CKD, though it did not reach statistical significance. However, the dose-response results suggest that more than seven servings per week should be avoided.

Citing Articles

Burden of cardiometabolic disease attributable to sugar sweetened beverages consumption in North Africa and the Middle East from 1990 to 2021.

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Global burden of chronic kidney disease due to dietary factors.

Yin L, Kuai M, Liu Z, Zou B, Wu P Front Nutr. 2025; 11:1522555.

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Trends and future predictions of chronic kidney disease due to diabetes mellitus type 2 attributable to dietary risks: insights based on GBD 2021 data.

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Dai X, Chen X, Jia L, Jing X, Pan X, Zhang X Front Nutr. 2024; 11:1401081.

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Non-Sugar-Sweetened Beverages and Risk of Chronic Diseases: An Umbrella Review of Meta-analyses of Prospective Cohort Studies.

Beigrezaei S, Raeisi-Dehkordi H, Hernandez Vargas J, Amiri M, Artola Arita V, van der Schouw Y Nutr Rev. 2024; 83(4):663-674.

PMID: 39325512 PMC: 11894252. DOI: 10.1093/nutrit/nuae135.

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