Analysis of Lipid Peroxidation by UPLC-MS/MS and Retinoprotective Effects of the Natural Polyphenol Pterostilbene

Overview

Journal Antioxidants (Basel)

Date 2021 Jan 27

PMID 33498744

Citations 7

Authors

Isabel Torres-Cuevas

Ivan Millan

Miguel Asensi

Maximo Vento

Camille Oger

Jean-Marie Galano

Thierry Durand

Angel L Ortega

Affiliations

Soon will be listed here.

Abstract

The loss of redox homeostasis induced by hyperglycemia is an early sign and key factor in the development of diabetic retinopathy. Due to the high level of long-chain polyunsaturated fatty acids, diabetic retina is highly susceptible to lipid peroxidation, source of pathophysiological alterations in diabetic retinopathy. Previous studies have shown that pterostilbene, a natural antioxidant polyphenol, is an effective therapy against diabetic retinopathy development, although its protective effects on lipid peroxidation are not well known. Plasma, urine and retinas from diabetic rabbits, control and diabetic rabbits treated daily with pterostilbene were analyzed. Lipid peroxidation was evaluated through the determination of derivatives from arachidonic, adrenic and docosahexaenoic acids by ultra-performance liquid chromatography coupled with tandem mass spectrometry. Diabetes increased lipid peroxidation in retina, plasma and urine samples and pterostilbene treatment restored control values, showing its ability to prevent early and main alterations in the development of diabetic retinopathy. Through our study, we are able to propose the use of a derivative of adrenic acid, 17()-10---Δ-11-dihomo-IsoF, for the first time, as a suitable biomarker of diabetic retinopathy in plasmas or urine.

Citing Articles

Adrenic acid: A promising biomarker and therapeutic target (Review).

Wang Z, Gao H, Ma X, Zhu D, Zhao L, Xiao W Int J Mol Med. 2024; 55(2).

PMID: 39575474 PMC: 11611323. DOI: 10.3892/ijmm.2024.5461.

Global trends in oxidative stress in the Retina: A bibliometric analysis of 2013-2023.

Xiong M, Yu C, Ren B, Zhong M, Lu J, Yuan C Heliyon. 2024; 10(10):e31620.

PMID: 38831806 PMC: 11145483. DOI: 10.1016/j.heliyon.2024.e31620.

Porous Se@SiO nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation.

Niu T, Shi X, Liu X, Wang H, Liu K, Xu Y Mol Med. 2024; 30(1):24.

PMID: 38321393 PMC: 10848509. DOI: 10.1186/s10020-024-00785-z.

m6A Modification-Association with Oxidative Stress and Implications on Eye Diseases.

Ni Y, Zhang H, Chu L, Zhao Y Antioxidants (Basel). 2023; 12(2).

PMID: 36830067 PMC: 9952187. DOI: 10.3390/antiox12020510.

Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.

Chen Y, Zhang H, Li Y, Wang T Oxid Med Cell Longev. 2023; 2023:8258354.

PMID: 36733420 PMC: 9889155. DOI: 10.1155/2023/8258354.

References

Aguirre L, Palacios-Ortega S, Fernandez-Quintela A, Hijona E, Bujanda L, Portillo M . Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats. Nutrients. 2019; 11(5). PMC: 6566509. DOI: 10.3390/nu11050961. View

Esterbauer H . Cytotoxicity and genotoxicity of lipid-oxidation products. Am J Clin Nutr. 1993; 57(5 Suppl):779S-785S; discussion 785S-786S. DOI: 10.1093/ajcn/57.5.779S. View

Suzumura A, Terao R, Kaneko H . Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases. Antioxidants (Basel). 2020; 9(10). PMC: 7600094. DOI: 10.3390/antiox9100920. View

Garcia-Blanco A, Pena-Bautista C, Oger C, Vigor C, Galano J, Durand T . Reliable determination of new lipid peroxidation compounds as potential early Alzheimer Disease biomarkers. Talanta. 2018; 184:193-201. DOI: 10.1016/j.talanta.2018.03.002. View

Semeraro F, Morescalchi F, Cancarini A, Russo A, Rezzola S, Costagliola C . Diabetic retinopathy, a vascular and inflammatory disease: Therapeutic implications. Diabetes Metab. 2019; 45(6):517-527. DOI: 10.1016/j.diabet.2019.04.002. View

Ghadiri Soufi F, Mohammad-nejad D, Ahmadieh H . Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor κB - apoptosis pathway. Pharmacol Rep. 2013; 64(6):1505-14. DOI: 10.1016/s1734-1140(12)70948-9. View

Longmire A, Roberts L, Morrow J . Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. Prostaglandins. 1994; 48(4):247-56. DOI: 10.1016/0090-6980(94)90011-6. View

Kersten E, Paun C, Schellevis R, Hoyng C, Delcourt C, Lengyel I . Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration. Surv Ophthalmol. 2017; 63(1):9-39. DOI: 10.1016/j.survophthal.2017.05.003. View

Wang M, Hsiao G, Al-Shabrawey M . Eicosanoids and Oxidative Stress in Diabetic Retinopathy. Antioxidants (Basel). 2020; 9(6). PMC: 7346161. DOI: 10.3390/antiox9060520. View

10.

Chang Y, Chang W, Hung K, Yang D, Cheng Y, Liao Y . The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 2014; 6:191. PMC: 4117985. DOI: 10.3389/fnagi.2014.00191. View

11.

Csala M, Kardon T, Legeza B, Lizak B, Mandl J, Margittai E . On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015; 1852(5):826-38. DOI: 10.1016/j.bbadis.2015.01.015. View

12.

Kumar B, Gupta S, Nag T, Srivastava S, Saxena R, Jha K . Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats. Exp Eye Res. 2014; 125:193-202. DOI: 10.1016/j.exer.2014.06.009. View

13.

Joussen A, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Dohmen S . Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002; 16(3):438-40. DOI: 10.1096/fj.01-0707fje. View

14.

Mondal L, Bhaduri G, Bhattacharya B . Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus. Indian J Ophthalmol. 2018; 66(4):535-540. PMC: 5892057. DOI: 10.4103/ijo.IJO_1121_17. View

15.

Pena-Bautista C, Carrascosa-Marco P, Oger C, Vigor C, Galano J, Durand T . Validated analytical method to determine new salivary lipid peroxidation compounds as potential neurodegenerative biomarkers. J Pharm Biomed Anal. 2018; 164:742-749. DOI: 10.1016/j.jpba.2018.11.043. View

16.

Song W, Lawson J, Reilly D, Rokach J, Chang C, Giasson B . Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. J Biol Chem. 2007; 283(1):6-16. DOI: 10.1074/jbc.M706124200. View

17.

de la Torre A, Lee Y, Mazzoni A, Guy A, Bultel-Ponce V, Durand T . Total syntheses and in vivo quantitation of novel neurofuran and dihomo-isofuran derived from docosahexaenoic acid and adrenic acid. Chemistry. 2014; 21(6):2442-6. DOI: 10.1002/chem.201405497. View

18.

Agrawal M, Kumar V, Singh A, Kashyap M, Khanna V, Siddiqui M . trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. ACS Chem Neurosci. 2013; 4(2):285-94. PMC: 3582290. DOI: 10.1021/cn300143m. View

19.

Wilkinson C, Ferris 3rd F, Klein R, Lee P, Agardh C, Davis M . Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003; 110(9):1677-82. DOI: 10.1016/S0161-6420(03)00475-5. View

20.

Roberts 2nd L, Montine T, Markesbery W, Tapper A, Hardy P, Chemtob S . Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem. 1998; 273(22):13605-12. DOI: 10.1074/jbc.273.22.13605. View