Regional Responses in Radiation-Induced Normal Tissue Damage

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Jan 27

PMID 33498403

Citations 16

Authors

Danielle C Voshart

Julia Wiedemann

Peter van Luijk

Lara Barazzuol

Affiliations

Soon will be listed here.

Abstract

Normal tissue side effects remain a major concern in radiotherapy. The improved precision of radiation dose delivery of recent technological developments in radiotherapy has the potential to reduce the radiation dose to organ regions that contribute the most to the development of side effects. This review discusses the contribution of regional variation in radiation responses in several organs. In the brain, various regions were found to contribute to radiation-induced neurocognitive dysfunction. In the parotid gland, the region containing the major ducts was found to be critical in hyposalivation. The heart and lung were each found to exhibit regional responses while also mutually affecting each other's response to radiation. Sub-structures critical for the development of side effects were identified in the pancreas and bladder. The presence of these regional responses is based on a non-uniform distribution of target cells or sub-structures critical for organ function. These characteristics are common to most organs in the body and we therefore hypothesize that regional responses in radiation-induced normal tissue damage may be a shared occurrence. Further investigations will offer new opportunities to reduce normal tissue side effects of radiotherapy using modern and high-precision technologies.

Citing Articles

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References

Qiu D, Kwong D, Chan G, Leung L, Khong P . Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity?. Int J Radiat Oncol Biol Phys. 2007; 69(3):846-51. DOI: 10.1016/j.ijrobp.2007.04.041. View

Jiang W, Lakshminarayanan P, Hui X, Han P, Cheng Z, Bowers M . Machine Learning Methods Uncover Radiomorphologic Dose Patterns in Salivary Glands that Predict Xerostomia in Patients with Head and Neck Cancer. Adv Radiat Oncol. 2019; 4(2):401-412. PMC: 6460328. DOI: 10.1016/j.adro.2018.11.008. View

Borras J, Lievens Y, Barton M, Corral J, Ferlay J, Bray F . How many new cancer patients in Europe will require radiotherapy by 2025? An ESTRO-HERO analysis. Radiother Oncol. 2016; 119(1):5-11. DOI: 10.1016/j.radonc.2016.02.016. View

Gui C, Vannorsdall T, Kleinberg L, Assadi R, Moore J, Hu C . A Prospective Cohort Study of Neural Progenitor Cell-Sparing Radiation Therapy Plus Temozolomide for Newly Diagnosed Patients With Glioblastoma. Neurosurgery. 2020; 87(1):E31-E40. PMC: 7293896. DOI: 10.1093/neuros/nyaa107. View

Robertson S, Quon H, Kiess A, Moore J, Yang W, Cheng Z . A data-mining framework for large scale analysis of dose-outcome relationships in a database of irradiated head and neck cancer patients. Med Phys. 2015; 42(7):4329-37. DOI: 10.1118/1.4922686. View

Maeda Y, Hoyer M, Lundby L, Norton C . Faecal incontinence following radiotherapy for prostate cancer: a systematic review. Radiother Oncol. 2011; 98(2):145-53. DOI: 10.1016/j.radonc.2010.12.004. View

Bhattacharya I, Hoskin P . Stereotactic body radiotherapy for spinal and bone metastases. Clin Oncol (R Coll Radiol). 2015; 27(5):298-306. DOI: 10.1016/j.clon.2015.01.030. View

van Nimwegen F, Schaapveld M, Janus C, Krol A, Raemaekers J, Kremer L . Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol. 2014; 32(29):3257-63. DOI: 10.1200/JCO.2013.54.4379. View

GRAHAM M, Purdy J, Emami B, Harms W, Bosch W, Lockett M . Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 1999; 45(2):323-9. DOI: 10.1016/s0360-3016(99)00183-2. View

10.

Huang E, Hope A, Lindsay P, Trovo M, El Naqa I, Deasy J . Heart irradiation as a risk factor for radiation pneumonitis. Acta Oncol. 2010; 50(1):51-60. PMC: 4041523. DOI: 10.3109/0284186X.2010.521192. View

11.

Aure M, Konieczny S, Ovitt C . Salivary gland homeostasis is maintained through acinar cell self-duplication. Dev Cell. 2015; 33(2):231-7. PMC: 4406828. DOI: 10.1016/j.devcel.2015.02.013. View

12.

Sandor N, Walter F, Bocsik A, Santha P, Schilling-Toth B, Lener V . Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice. PLoS One. 2014; 9(11):e112397. PMC: 4231057. DOI: 10.1371/journal.pone.0112397. View

13.

Nieman B, de Guzman A, Gazdzinski L, Lerch J, Chakravarty M, Pipitone J . White and Gray Matter Abnormalities After Cranial Radiation in Children and Mice. Int J Radiat Oncol Biol Phys. 2015; 93(4):882-91. DOI: 10.1016/j.ijrobp.2015.07.2293. View

14.

Mizumatsu S, Monje M, Morhardt D, Rola R, Palmer T, Fike J . Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 2003; 63(14):4021-7. View

15.

Jadon R, Higgins E, Hanna L, Evans M, Coles B, Staffurth J . A systematic review of dose-volume predictors and constraints for late bowel toxicity following pelvic radiotherapy. Radiat Oncol. 2019; 14(1):57. PMC: 6448293. DOI: 10.1186/s13014-019-1262-8. View

16.

Tran T, Jilaveanu L, Omuro A, Chiang V, Huttner A, Kluger H . Complications associated with immunotherapy for brain metastases. Curr Opin Neurol. 2019; 32(6):907-916. PMC: 7398556. DOI: 10.1097/WCO.0000000000000756. View

17.

Peiffer A, Leyrer C, Greene-Schloesser D, Shing E, Kearns W, Hinson W . Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Neurology. 2013; 80(8):747-53. PMC: 3589296. DOI: 10.1212/WNL.0b013e318283bb0a. View

18.

Zhou K, Bostrom M, Ek C, Li T, Xie C, Xu Y . Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat cerebellum. Sci Rep. 2017; 7:46181. PMC: 5382769. DOI: 10.1038/srep46181. View

19.

Acharya S, Wu S, Ashford J, Tinkle C, Lucas J, Qaddoumi I . Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: a 10-year neurocognitive longitudinal study. Neuro Oncol. 2019; 21(9):1175-1183. PMC: 7594551. DOI: 10.1093/neuonc/noz068. View

20.

De Ruysscher D, Niedermann G, Burnet N, Siva S, Lee A, Hegi-Johnson F . Radiotherapy toxicity. Nat Rev Dis Primers. 2019; 5(1):13. DOI: 10.1038/s41572-019-0064-5. View