Hippo Pathway Effectors YAP and TAZ and Their Association with Skeletal Muscle Ageing

Overview

Journal J Physiol Biochem

Specialties Biochemistry
Physiology

Date 2021 Jan 26

PMID 33495890

Citations 10

Authors

Iwan Setiawan

Ardo Sanjaya

Ronny Lesmana

Paul M Yen

Hanna Goenawan

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satellite cell functions, on supporting cells such as fibroblasts, and autophagy. YAP/TAZ was found to regulate both myoblast proliferation and differentiation, albeit with unique roles. Additionally, YAP/TAZ has different functions depending on the expressing cell type, making simple inference of their effects difficult. Studies in cancers have shown that the Hippo pathway influenced the autophagy pathway, although with mixed results. Most of the present researches on YAP/TAZ are focused on its oncogenicity and further studies are needed to translate these findings to physiological ageing. Taken together, the modulation of YAP/TAZ or the Hippo pathway in general may offer potential new strategies for the prevention or treatment of ageing.

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