Rapid Four-component Synthesis of Dihydropyrano[2,3-c]pyrazoles Using Nano-eggshell/Ti(IV) As a Highly Compatible Natural Based Catalyst

Overview

Journal BMC Chem

Publisher Springer Nature

Specialty Chemistry

Date 2021 Jan 26

PMID 33494797

Citations 2

Authors

Arefeh Dehghani Tafti

Bi Bi Fatemeh Mirjalili

Abdolhamid Bamoniri

Naeimeh Salehi

Affiliations

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Abstract

Nano-eggshell/Ti(IV) as a novel naturally based catalyst was prepared, characterized and applied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. The characterization of nano-eggshell/Ti(IV) was performed using Fourier Transform Infrared spectroscopy, X-ray Diffraction, Field Emission Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, and Thermo Gravimetric Analysis. Dihydropyrano[2,3-c]pyrazoles were synthesized in the presence of nano-eggshell/Ti(IV) via a four component reaction of aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate at room temperature under solvent free conditions. The principal affairs of this procedure are mild condition, short reaction times, easy work-up, high yields, reusability of the catalyst and the absence of toxic organic solvents.

Citing Articles

Green multicomponent synthesis of pyrano[2,3-]pyrazole derivatives: current insights and future directions.

Ahmad A, Rao S, Shetty N RSC Adv. 2023; 13(41):28798-28833.

PMID: 37790089 PMC: 10543893. DOI: 10.1039/d3ra05570a.

A green protocol ball milling synthesis of dihydropyrano[2,3-c]pyrazole using nano-silica/aminoethylpiperazine as a metal-free catalyst.

Mallah D, Mirjalili B BMC Chem. 2023; 17(1):10.

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