Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 26

PMID 33494373

Citations 7

Authors

Michal Fiedorowicz

Tomasz Choragiewicz

Waldemar A Turski

Tomasz Kocki

Dominika Nowakowska

Kamila Wertejuk

Agnieszka Kaminska

Teresio Avitabile

Marlena Welniak-Kaminska

Pawel Grieb

Sandrine Zweifel

Robert Rejdak

Mario Damiano Toro

Affiliations

Soon will be listed here.

Abstract

Background: It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina. This study aimed to verify the hypothesis that alterations of tryptophan (TRP) metabolism in DBA/2J mice is not limited to the retina.

Methods: Samples of the retinal tissue and serum were collected from DBA/2J mice (6 and 10 months old) and control C57Bl/6 mice of the same age. The concentration of TRP, KYNA, kynurenine (KYN), and 3-hydroxykynurenine (3OH-K) was measured by HPLC. The activity of indoleamine 2,3-dioxygenase (IDO) was also determined as a KYN/TRP ratio.

Results: TRP, KYNA, L-KYN, and 3OH-K concentration were significantly lower in the retinas of DBA/2J mice than in C57Bl/6 mice. 3OH-K concentration was higher in older mice in both strains. Serum TRP, L-KYN, and KYNA concentrations were lower in DBA/2J than in age-matched controls. However, serum IDO activity did not differ significantly between compared groups and strains.

Conclusions: Alterations of the TRP pathway seem not to be limited to the retina in the murine model of hereditary glaucoma.

Citing Articles

A Review on the Role and Function of Cinnabarinic Acid, a "Forgotten" Metabolite of the Kynurenine Pathway.

Gawel K Cells. 2024; 13(5.

PMID: 38474418 PMC: 10930587. DOI: 10.3390/cells13050453.

Efficacy of Continuous-Wave Transscleral Cyclophotocoagulation Post-Pars Plana Vitrectomy in Glaucoma Patients: A Retrospective Study from Poland.

Kuciel-Polczak I, Kawka-Osuch M, Krysik K, Dobrowolski D, Janiszewska-Bil D, Wylegala E Med Sci Monit. 2023; 29:e941770.

PMID: 38130054 PMC: 10750432. DOI: 10.12659/MSM.941770.

Association between dietary calcium, potassium, and magnesium consumption and glaucoma.

Zhang Y, Zhao Z, Ma Q, Li K, Zhao X, Jia Z PLoS One. 2023; 18(10):e0292883.

PMID: 37851631 PMC: 10584168. DOI: 10.1371/journal.pone.0292883.

Decoding the Complex Crossroad of Tryptophan Metabolic Pathways.

Mondanelli G, Volpi C, Orabona C Int J Mol Sci. 2022; 23(2).

PMID: 35054973 PMC: 8776215. DOI: 10.3390/ijms23020787.

The Effect of Ocular Perfusion Pressure on Retinal Thickness in Young People with Presumed Systemic Hypotension.

Vawda N, Munsamy A Vision (Basel). 2021; 5(3).

PMID: 34287377 PMC: 8293322. DOI: 10.3390/vision5030036.

References

Savitz J . The kynurenine pathway: a finger in every pie. Mol Psychiatry. 2019; 25(1):131-147. PMC: 6790159. DOI: 10.1038/s41380-019-0414-4. View

Cheng H, Nair G, Walker T, Kim M, Pardue M, Thule P . Structural and functional MRI reveals multiple retinal layers. Proc Natl Acad Sci U S A. 2006; 103(46):17525-30. PMC: 1859962. DOI: 10.1073/pnas.0605790103. View

Wong A, Brown R . Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice. Neurobiol Aging. 2006; 28(10):1577-93. DOI: 10.1016/j.neurobiolaging.2006.07.023. View

Jonas J, Aung T, Bourne R, Bron A, Ritch R, Panda-Jonas S . Glaucoma. Lancet. 2017; 390(10108):2183-2193. DOI: 10.1016/S0140-6736(17)31469-1. View

Fiedorowicz M, Orzel J, Kossowski B, Welniak-Kaminska M, Choragiewicz T, Swiatkiewicz M . Anterograde Transport in Axons of the Retinal Ganglion Cells and its Relationship to the Intraocular Pressure during Aging in Mice with Hereditary Pigmentary Glaucoma. Curr Eye Res. 2017; 43(4):539-546. DOI: 10.1080/02713683.2017.1416147. View

Libby R, Anderson M, Pang I, Robinson Z, Savinova O, Cosma I . Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci. 2005; 22(5):637-48. DOI: 10.1017/S0952523805225130. View

Cone F, Steinhart M, Oglesby E, Kalesnykas G, Pease M, Quigley H . The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma. Exp Eye Res. 2012; 99:27-35. PMC: 3375133. DOI: 10.1016/j.exer.2012.04.006. View

John S, Smith R, Savinova O, Hawes N, Chang B, Turnbull D . Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci. 1998; 39(6):951-62. View

Rejdak R, Zarnowski T, Turski W, Kocki T, Zagorski Z, Zrenner E . Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage. Vision Res. 2003; 43(5):497-503. DOI: 10.1016/s0042-6989(02)00682-x. View

10.

Harper M, Woll A, Evans L, Delcau M, Akurathi A, Hedberg-Buenz A . Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury. Invest Ophthalmol Vis Sci. 2019; 60(13):4159-4170. PMC: 6785841. DOI: 10.1167/iovs.19-27565. View

11.

Posarelli C, Ortenzio P, Ferreras A, Toro M, Passani A, Loiudice P . Twenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients. J Ophthalmol. 2019; 2019:9890831. PMC: 6369465. DOI: 10.1155/2019/9890831. View

12.

Dengler-Crish C, Smith M, Inman D, Wilson G, Young J, Crish S . Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma. Front Neurosci. 2014; 8:290. PMC: 4166356. DOI: 10.3389/fnins.2014.00290. View

13.

Guillemin G . Quinolinic acid: neurotoxicity. FEBS J. 2012; 279(8):1355. DOI: 10.1111/j.1742-4658.2012.08493.x. View

14.

Scholz M, Buder T, Seeber S, Adamek E, Becker C, Lutjen-Drecoll E . Dependency of intraocular pressure elevation and glaucomatous changes in DBA/2J and DBA/2J-Rj mice. Invest Ophthalmol Vis Sci. 2008; 49(2):613-21. DOI: 10.1167/iovs.07-0745. View

15.

Jacobs K, Castellano-Gonzalez G, Guillemin G, Lovejoy D . Major Developments in the Design of Inhibitors along the Kynurenine Pathway. Curr Med Chem. 2017; 24(23):2471-2495. PMC: 5748880. DOI: 10.2174/0929867324666170502123114. View

16.

Parrott J, OConnor J . Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology. Front Psychiatry. 2015; 6:116. PMC: 4542134. DOI: 10.3389/fpsyt.2015.00116. View

17.

Pierozan P, Biasibetti-Brendler H, Schmitz F, Ferreira F, Pessoa-Pureur R, Wyse A . Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum. Mol Neurobiol. 2017; 55(6):5111-5124. DOI: 10.1007/s12035-017-0749-2. View

18.

Zhao J, Gao P, Zhu D . Optimization of Zn2+-containing mobile phase for simultaneous determination of kynurenine, kynurenic acid and tryptophan in human plasma by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878(5-6):603-8. DOI: 10.1016/j.jchromb.2010.01.006. View

19.

Borisova M, Snytnikova O, Litvinova E, Achasova K, Babochkina T, Pindyurin A . Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis. Nutrients. 2020; 12(2). PMC: 7071335. DOI: 10.3390/nu12020445. View

20.

Kasi A, Faiq M, Chan K . imaging of structural, metabolic and functional brain changes in glaucoma. Neural Regen Res. 2018; 14(3):446-449. PMC: 6334611. DOI: 10.4103/1673-5374.243712. View