Article: Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy

We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms.

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References

1.

SALVIDIO E, PANNACCIULLI I, Tizianello A, Gaetani G, Paravidino G . Glucose-6-phosphate dehydrogenase deficiency in Italy. A study of the distribution and severity of the enzymatic defect. Acta Haematol. 1969; 41(6):331-40. DOI: 10.1159/000208870. View

2.

N Naik S, Anderson D . G.-6-P.D. deficiency and cancer. Lancet. 1970; 1(7655):1060-1. DOI: 10.1016/s0140-6736(70)91195-5. View

3.

SULIS E . G.-6-P.D. deficiency and cancer. Lancet. 1972; 1(7761):1185. DOI: 10.1016/s0140-6736(72)91416-x. View

4.

Rinaldi A, Filippi G, SINISCALCO M . Variability of red cell phenotypes between and within individuals in an unbiased sample of 77 heterozygotes for G6PD deficiency in Sardinia. Am J Hum Genet. 1976; 28(5):496-505. PMC: 1685117. View

5.

Luzzatto L, Usanga E, Bienzle U, Esan G, Fusuan F . Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells. Science. 1979; 205(4413):1418-20. DOI: 10.1126/science.472761. View

6.

Ferraris A, Canepa L, Massimo L, Dini G, Broccia G, Meloni T . Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia. Am J Hematol. 1985; 20(1):81-3. DOI: 10.1002/ajh.2830200111. View

7.

Gaetani G, Ferraris A, Galiano S, Giuntini P, Canepa L, DUrso M . Primary thrombocythemia: clonal origin of platelets, erythrocytes, and granulocytes in a GdB/GdMediterranean subject. Blood. 1982; 59(1):76-9. View

8.

Ferraris A, Canepa L, Mareni C, BAULE G, Meloni T, SALVIDIO E . Reexpression of normal stem cells in erythroleukemia during remission. Blood. 1983; 62(1):177-9. View

9.

Arnold A, Cossman J, Bakhshi A, Jaffe E, Waldmann T, Korsmeyer S . Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med. 1983; 309(26):1593-9. DOI: 10.1056/NEJM198312293092601. View

10.

Ferraris A, Broccia G, Meloni T, Canepa L, Sessarego M, Gaetani G . Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. Blood. 1984; 64(4):817-20. View

11.

Ferraris A, Giuntini P, Galiano S, Gaetani G . 2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism. Am J Hum Genet. 1981; 33(2):307-13. PMC: 1684947. View

Glucose 6-phosphate Dehydrogenase Deficiency and Incidence of Hematologic Malignancy