The Prion Protein is Not Required for Peripheral Nerve De- and Remyelination After Crush Injury

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Jan 22

PMID 33481951

Citations 2

Authors

Anna Henzi

Adriano Aguzzi

Affiliations

Soon will be listed here.

Abstract

The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates the adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade of molecular signals. Because Adgrg6 is crucial for peripheral myelin development and regeneration after nerve injury, we investigated the role of PrP in peripheral nerve repair. We performed experimental sciatic nerve crush injuries in co-isogenic wild-type and PrP-deficient mice, and examined peripheral nerve repair processes. Generation of repair Schwann cells, macrophage recruitment and remyelination were similar in PrP-deficient and wild-type mice. We conclude that PrP is dispensable for sciatic nerve de- and remyelination after crush injury. Adgrg6 may sustain its function in peripheral nerve repair independently of its activation by PrP.

Citing Articles

Prion Protein: The Molecule of Many Forms and Faces.

Kovac V, Serbec V Int J Mol Sci. 2022; 23(3).

PMID: 35163156 PMC: 8835406. DOI: 10.3390/ijms23031232.

Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases.

Arthur-Farraj P, Coleman M Neurotherapeutics. 2021; 18(4):2200-2221.

PMID: 34595734 PMC: 8804151. DOI: 10.1007/s13311-021-01125-3.

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