Anthropometric Risk Factors for Ovarian Cancer in the NIH-AARP Diet and Health Study

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 2021 Jan 22

PMID 33481137

Citations 2

Authors

Sebastian E Baumeister

Inga Schlecht

Britton Trabert

Michael Nolde

Christa Meisinger

Michael F Leitzmann

Affiliations

Soon will be listed here.

Abstract

Objective: Identifying potentially modifiable risk factors for ovarian cancer is essential for prevention because this cancer is predominantly detected at a late stage. Here, we estimated the relations of general adiposity and measures reflecting body fat distribution to the risk of epithelial ovarian cancer.

Methods: We ascertained 683 ovarian epithelial cancers (343 high-grade serous, 141 non-high grade serous) among 145,575 women, aged 50-72 years (median follow-up 12.6 years), from the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study. Using Cox models, we estimated confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for associations of overall ovarian cancer, high-grade serous and non-high-grade serous carcinoma with body mass index, waist circumference, hip circumference, waist-hip ratio, waist-height ratio, body adiposity index, body shape index, and abdominal volume index.

Results: Anthropometric measures were unrelated to overall ovarian cancer, high-grade serous cancer, and non-high-grade serous cancer. For example, the HR for overall ovarian cancer per standard deviation increment of body mass index at baseline was 0.98 (95% CI 0.88-1.10). Similar associations were observed with measurements of body fat distribution.

Conclusion: These results do not indicate that adult adiposity is associated with ovarian cancer risk in post-menopausal women.

Citing Articles

Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index.

Hawwash N, Sperrin M, Martin G, Joshu C, Florido R, Platz E Br J Cancer. 2024; 131(10):1623-1634.

PMID: 39367274 PMC: 11554801. DOI: 10.1038/s41416-024-02860-y.

Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies.

Shi X, Deng G, Wen H, Lin A, Wang H, Zhu L J Glob Health. 2024; 14:04067.

PMID: 38547495 PMC: 10978059. DOI: 10.7189/jogh.14.04067.

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