Effects of Ionic Liquids on Metalloproteins

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Jan 22

PMID 33478102

Citations 3

Authors

Aashka Y Patel

Keertana S Jonnalagadda

Nicholas Paradis

Timothy D Vaden

Chun Wu

Gregory A Caputo

Affiliations

Soon will be listed here.

Abstract

In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein molecules. Notably, many of the proteins used in industrial applications are involved in redox chemistry, and thus often contain metal ions or metal-associated cofactors. In this review article, we focus on the current understanding of protein structure-function relationship in the presence of ILs, specifically focusing on the effect of ILs on metal containing proteins.

Citing Articles

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review.

Zhuo Y, Cheng H, Zhao Y, Cui H Pharmaceutics. 2024; 16(1).

PMID: 38276519 PMC: 10818567. DOI: 10.3390/pharmaceutics16010151.

Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids.

Patel R, Clark A, DeStefano G, DeStefano I, Gogoj H, Gray E Biochem Biophys Rep. 2022; 30:101242.

PMID: 35280523 PMC: 8907678. DOI: 10.1016/j.bbrep.2022.101242.

Effect of Hydrated Ionic Liquid on Photocycle and Dynamics of Photoactive Yellow Protein.

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PMID: 34361707 PMC: 8348629. DOI: 10.3390/molecules26154554.

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