Effects of Larval Rearing Substrates on Some Life-table Parameters of Lutzomyia Longipalpis Sand Flies

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2021 Jan 21

PMID 33476330

Authors

Kelsilandia Aguiar Martins

Maria Helena de Athayde Meirelles

Tiago Feitosa Mota

Ibrahim Abbasi

Artur Trancoso Lopo de Queiroz

Claudia Ida Brodskyn

Patricia Sampaio Tavares Veras

Deborah Bittencourt Mothe Fraga

Alon Warburg

Affiliations

Soon will be listed here.

Abstract

Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sand fly Lutzomyia longipalpis affects their oviposition, development, microbiome, and susceptibility to Leishmania by rearing L. longipalpis on substrates collected from an endemic area for leishmaniasis in Brazil. The results showed that female L. longipalpis select the oviposition site based on its potential to promote larval maturation and while composting cashew leaf litter hindered the development, larvae reared on chicken feces developed rapidly. Typical gut microbial profiles were found in larvae reared upon cashew leaf litter. Adult females from larvae reared on substrate collected in chicken coops were infected with Leishmania infantum, indicating that they were highly susceptible to the parasite. In conclusion, the larval breeding sites can exert an important role in the epidemiology of leishmaniasis.

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