Interferon Regulatory Factor 1 (IRF1) and Anti-pathogen Innate Immune Responses

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2021 Jan 21

PMID 33476326

Citations 113

Authors

Hui Feng

Yi-Bing Zhang

Jian-Fang Gui

Stanley M Lemon

Daisuke Yamane

Affiliations

Soon will be listed here.

Abstract

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.

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