Phage Therapy As Strategy to Face Post-antibiotic Era: a Guide to Beginners and Experts

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 2021 Jan 21

PMID 33474609

Citations 17

Authors

Sabrina Royer

Alexia Pinheiro Morais

Deivid William da Fonseca Batistao

Affiliations

Soon will be listed here.

Abstract

Interest in the therapeutic use of bacteriophages (phages) has emerged in recent years, driven mainly by the antimicrobial resistance crisis. This review aimed to summarize some important studies addressing the use of phages as a therapeutic alternative for multiresistant bacterial infections. To this end, a literature search was conducted to address the efficacy and versatility of phage therapy, the advantages and disadvantages of its use, and potential limitations for the application of phage therapy that need to be overcome, especially in Western countries. Thus, this review highlights that phage therapy may be a promising route in the treatment of infections caused by multidrug-resistant pathogens and that a combined approach has the potential to prolong the life of the current available antimicrobials. In addition, standardized clinical trials using monoclonal or polyclonal phages, alone or in combination with antimicrobials, are crucial to determine the real potential of these treatments in clinical practice.

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