Differences in Initial Versus Recurrent Diabetic Foot Ulcers at a Specialized Tertiary Diabetic Foot Care Center in China

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2021 Jan 21

PMID 33472497

Citations 8

Authors

Yuxia Cheng

Ping Zu

Jie Zhao

Lintao Shi

Hongyan Shi

Mei Zhang

Aihong Wang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the characteristics of diabetic foot ulcer (DFU) recurrence.

Methods: A total of 573 patients with DFUs were recruited and divided into an initial group (395 patients) and a recurrence group (178 patients). The factors related to recurrence were analyzed using multivariate regression.

Results: The recurrence group had longer diabetes duration (odds ratio [OR] 192; 95% confidence interval 120, 252 vs. 156; 96, 240); lower glycated hemoglobin levels (OR 8.1; 95% CI 6.8, 9.6 vs. 9.1; 7.4, 10.5), and higher rates than the initial group of amputation (37.5% vs. 2.0%), history of vascular intervention (21.3% vs. 3.9%), retinopathy (77.7% vs. 64.7%), callus (44.4% vs. 20.8%), foot deformity (51.2% vs. 24.6%), and outdoor sports shoe wearing (34.0% vs. 21.2%). Multiple factor logistic regression analysis showed that diabetes duration (OR 1.004), callus (OR 2.769), vascular intervention (OR 2.824) and amputation (OR 22.256) were independent risk factors for DFU recurrence.

Conclusion: Diabetes duration, callus, history of vascular intervention, and amputation were independent risk factors for recurrent DFUs in a cohort of Chinese patients with active DFU. The prevention and treatment of DFUs, especially callus treatment, foot care, and blood glucose control, should be improved in China.

Citing Articles

Risk factors associated with the recurrence of diabetic foot ulcers: A meta-analysis.

Lin C, Tian J, Zhang Z, Zheng C, Liu J PLoS One. 2025; 20(2):e0318216.

PMID: 39951451 PMC: 11828396. DOI: 10.1371/journal.pone.0318216.

Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers: a systematic review and meta-analysis.

Zhang Y, Liu H, Yang Y, Feng C, Cui L Front Endocrinol (Lausanne). 2024; 15:1405301.

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The risk factors in diabetic foot ulcers and predictive value of prognosis of wound tissue vascular endothelium growth factor.

Xu J, Gao J, Li H, Zhu Z, Liu J, Gao C Sci Rep. 2024; 14(1):14120.

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[Construction and preliminary validation of a risk prediction model for the recurrence of diabetic foot ulcer in diabetic patients].

Guo Q, Ouyang J, Rao J, Zhang Y, Yu L, Xu W Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023; 39(12):1149-1157.

PMID: 38129301 PMC: 11630263. DOI: 10.3760/cma.j.cn501225-20231101-00166.

The Validity and Efficacy of a Preventative Intervention Model for Reducing Ulcer Recurrence in Diabetic Patients in Indonesia.

Jais S, Pratama K, Pradika J, Haryanto H SAGE Open Nurs. 2023; 9:23779608231179549.

PMID: 37334064 PMC: 10272669. DOI: 10.1177/23779608231179549.

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