Sex Bias of Females in Survival from Cancer and Infections. Is X the Answer?
Overview
Affiliations
Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in men and women with a preponderance of genes involved in immune responses being expressed in women. Important findings have been that some of the genes are important epigenetic regulators that play fundamental roles in immune responses.
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Hersey P, Tseng H, Alavi S, Tiffen J Pigment Cell Melanoma Res. 2024; 38(1):e13194.
PMID: 39180225 PMC: 11681842. DOI: 10.1111/pcmr.13194.
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PMID: 38133335 PMC: 10745854. DOI: 10.3390/pathogens12121452.
Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics.
Migliore L, Nicoli V, Stoccoro A Biomedicines. 2021; 9(6).
PMID: 34200989 PMC: 8228628. DOI: 10.3390/biomedicines9060652.