Astaxanthin-, β-Carotene-, and Resveratrol-Rich Foods Support Resistance Training-Induced Adaptation

Overview

Journal Antioxidants (Basel)

Date 2021 Jan 20

PMID 33466842

Citations 5

Authors

Aki Kawamura

Wataru Aoi

Ryo Abe

Yukiko Kobayashi

Masashi Kuwahata

Akane Higashi

Affiliations

Soon will be listed here.

Abstract

Resistance training adaptively increases the muscle strength associated with protein anabolism. Previously, we showed that the combined intake of astaxanthin, β-carotene, and resveratrol can accelerate protein anabolism in the skeletal muscle of mice. The purpose of this study was to investigate the effect of anabolic nutrient-rich foods on muscle adaptation induced by resistance training. Twenty-six healthy men were divided into control and intervention groups. All participants underwent a resistance training program twice a week for 10 weeks. Astaxanthin-, β-carotene-, and resveratrol-rich foods were provided to the intervention group. Body composition, nutrient intake, maximal voluntary contraction of leg extension, oxygen consumption, and serum carbonylated protein level were measured before and after training. The skeletal muscle mass was higher after training than before training in both groups ( < 0.05). Maximal voluntary contraction was increased after training in the intervention group ( < 0.05), but not significantly increased in the control group. Resting oxygen consumption was higher after training in the intervention group only ( < 0.05). As an oxidative stress marker, serum carbonylated protein level tended to be lower immediately after exercise than before exercise in the intervention group only ( = 0.056). Intake of astaxanthin-, β-carotene-, and resveratrol-rich foods supported resistance training-induced strength and metabolic adaptations.

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References

Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, Boncompagni S . Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab. 2008; 8(5):425-36. DOI: 10.1016/j.cmet.2008.09.002. View

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F . Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127(6):1109-22. DOI: 10.1016/j.cell.2006.11.013. View

Tarnopolsky M, Atkinson S, MacDougall J, Chesley A, Phillips S, Schwarcz H . Evaluation of protein requirements for trained strength athletes. J Appl Physiol (1985). 1992; 73(5):1986-95. DOI: 10.1152/jappl.1992.73.5.1986. View

Kawamura A, Aoi W, Abe R, Kobayashi Y, Wada S, Kuwahata M . Combined intake of astaxanthin, β-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice. Nutrition. 2019; 69:110561. DOI: 10.1016/j.nut.2019.110561. View

Flanagan S, Looney D, Miller M, DuPont W, Pryor L, Creighton B . The Effects of Nitrate-Rich Supplementation on Neuromuscular Efficiency during Heavy Resistance Exercise. J Am Coll Nutr. 2016; 35(2):100-7. DOI: 10.1080/07315724.2015.1081572. View

Goto S, Kogure K, Abe K, Kimata Y, Kitahama K, Yamashita E . Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim Biophys Acta. 2001; 1512(2):251-8. DOI: 10.1016/s0005-2736(01)00326-1. View

Achten J, Jeukendrup A . Maximal fat oxidation during exercise in trained men. Int J Sports Med. 2003; 24(8):603-8. DOI: 10.1055/s-2003-43265. View

Bender D, Townsend J, Vantrease W, Marshall A, Henry R, Heffington S . Acute beetroot juice administration improves peak isometric force production in adolescent males. Appl Physiol Nutr Metab. 2018; 43(8):816-821. DOI: 10.1139/apnm-2018-0050. View

Gomez-Cabrera M, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo F . Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008; 87(1):142-9. DOI: 10.1093/ajcn/87.1.142. View

10.

Jia Z, Zhu H, Misra B, Mahaney J, Li Y, Misra H . EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrol. Mol Cell Biochem. 2008; 313(1-2):187-94. DOI: 10.1007/s11010-008-9756-y. View

11.

Scheffer D, Silva L, Tromm C, da Rosa G, Silveira P, De Souza C . Impact of different resistance training protocols on muscular oxidative stress parameters. Appl Physiol Nutr Metab. 2012; 37(6):1239-46. DOI: 10.1139/h2012-115. View

12.

Nakano M, Onodera A, Saito E, Tanabe M, Yajima K, Takahashi J . Effect of astaxanthin in combination with alpha-tocopherol or ascorbic acid against oxidative damage in diabetic ODS rats. J Nutr Sci Vitaminol (Tokyo). 2008; 54(4):329-34. DOI: 10.3177/jnsv.54.329. View

13.

Moopanar T, Allen D . Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. J Physiol. 2005; 564(Pt 1):189-99. PMC: 1456045. DOI: 10.1113/jphysiol.2005.083519. View

14.

Patti M, Brambilla E, Luzi L, Landaker E, Kahn C . Bidirectional modulation of insulin action by amino acids. J Clin Invest. 1998; 101(7):1519-29. PMC: 508730. DOI: 10.1172/JCI1326. View

15.

Niki E, Saito T, Kawakami A, Kamiya Y . Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. J Biol Chem. 1984; 259(7):4177-82. View

16.

Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H . Oxidative stress and delayed-onset muscle damage after exercise. Free Radic Biol Med. 2004; 37(4):480-7. DOI: 10.1016/j.freeradbiomed.2004.05.008. View

17.

Carnio S, LoVerso F, Baraibar M, Longa E, Khan M, Maffei M . Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Rep. 2014; 8(5):1509-21. PMC: 4534571. DOI: 10.1016/j.celrep.2014.07.061. View

18.

Gallagher D, Belmonte D, Deurenberg P, Wang Z, KRASNOW N, Pi-Sunyer F . Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass. Am J Physiol. 1998; 275(2):E249-58. DOI: 10.1152/ajpendo.1998.275.2.E249. View

19.

Narici M, Hoppeler H, Kayser B, Landoni L, Claassen H, Gavardi C . Human quadriceps cross-sectional area, torque and neural activation during 6 months strength training. Acta Physiol Scand. 1996; 157(2):175-86. DOI: 10.1046/j.1365-201X.1996.483230000.x. View

20.

Jang Y, Lustgarten M, Liu Y, Muller F, Bhattacharya A, Liang H . Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J. 2009; 24(5):1376-90. PMC: 2987499. DOI: 10.1096/fj.09-146308. View