Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 20

PMID 33466437

Citations 17

Authors

Simone Rentschler

Lars Kaiser

Hans-Peter Deigner

Affiliations

Soon will be listed here.

Abstract

Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy.

Citing Articles

Detection of antimicrobial resistance via state-of-the-art technologies versus conventional methods.

Elbehiry A, Marzouk E, Abalkhail A, Abdelsalam M, Mostafa M, Alasiri M Front Microbiol. 2025; 16:1549044.

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Novel Method for the Rapid Establishment of Antibiotic Susceptibility Profiles in Bacterial Strains Linked to Musculoskeletal Infections Using Scattered Light Integrated Collector Technology.

Bertheloot D, Nessler V, Assaf E, Amerschlager C, Ali K, Ossendorff R Int J Mol Sci. 2025; 26(4).

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An Overview of the Recent Advances in Antimicrobial Resistance.

Oliveira M, Antunes W, Mota S, Madureira-Carvalho A, Dinis-Oliveira R, Dias da Silva D Microorganisms. 2024; 12(9).

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