Analysis of , and Genes Polymorphism in Four Rabbit Breeds with Different Coat Colors

Overview

Journal Animals (Basel)

Date 2021 Jan 20

PMID 33466315

Citations 13

Authors

Xianbo Jia

Peng Ding

Shiyi Chen

Shaokang Zhao

Jie Wang

Songjia Lai

Affiliations

Soon will be listed here.

Abstract

Pigmentation genes such as , and play a major role in rabbit coat color. To understand the genotypic profile underlying coat color in indigenous Chinese rabbit breeds, portions of the above-mentioned genes were amplified and variations in them were analyzed by DNA sequencing. Based on the analysis of 24 Tianfu black rabbits, 24 Sichuan white rabbits, 24 Sichuan gray rabbits, and 24 Fujian yellow rabbits, two indels in , three SNPs in , five SNPs (single nucleotide polymorphisms) in , one SNP in , and three SNPs in were discovered. These variations have low-to-moderate polymorphism, and there are significant differences in their distribution among the different breeds ( < 0.05). These results provide more information regarding the genetic background of these native rabbit breeds and reveal their high-quality genetic resources.

Citing Articles

MLPH regulates EMT in pancreatic adenocarcinoma through the PI3K-AKT signaling pathway.

Wei M, Yang X, Yang X, Huang Y, Yuan Z, Huang J J Cancer. 2024; 15(17):5828-5838.

PMID: 39308678 PMC: 11414609. DOI: 10.7150/jca.94573.

Coat colour in marsupials: genetic variants at the locus determine grey and black fur of the brushtail possum.

Bond D, Veale A, Alexander A, Hore T R Soc Open Sci. 2024; 11(7):240806.

PMID: 39086822 PMC: 11288674. DOI: 10.1098/rsos.240806.

Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes.

Liu X, Peng Y, Zhang X, Wang X, Chen W, Kou X Animals (Basel). 2024; 14(12).

PMID: 38929421 PMC: 11200706. DOI: 10.3390/ani14121802.

Skin proteomic screening and functional analysis of differential proteins associated with coat color in sheep (Ovis aries).

Yin Z, Hao S, Zhao Y, Li J, Cui Y, Ge Y Anim Biosci. 2024; 37(9):1503-1516.

PMID: 38754850 PMC: 11366522. DOI: 10.5713/ab.24.0014.

Melanophilin Polymorphism in Ferrets of Different Color.

Kosovsky G, Glazko V, Abramov O, Glazko T Dokl Biochem Biophys. 2024; 513(Suppl 1):S12-S17.

PMID: 38189891 DOI: 10.1134/S1607672923700655.

References

Benned-Jensen T, Mokrosinski J, Rosenkilde M . The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. PLoS One. 2011; 6(9):e24644. PMC: 3172247. DOI: 10.1371/journal.pone.0024644. View

Zhang X, Li W, Liu C, Peng X, Lin J, He S . Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9. Sci Rep. 2017; 7(1):8149. PMC: 5557758. DOI: 10.1038/s41598-017-08636-0. View

Paris J, Letko A, Hafliger I, Ammann P, Flury C, Drogemuller C . Identification of two TYRP1 loss-of-function alleles in Valais Red sheep. Anim Genet. 2019; 50(6):778-782. DOI: 10.1111/age.12863. View

Vidal O . Deleterious mutations of MC1R in guinea pig. Anim Genet. 2018; 49(5):498-499. DOI: 10.1111/age.12708. View

Liu Q, Cheng J, Lu Y, Zhou J, Wang L, Yang C . The clinical and genetic research of Waardenburg syndrome type I and II in Chinese families. Int J Pediatr Otorhinolaryngol. 2019; 130:109806. DOI: 10.1016/j.ijporl.2019.109806. View

Du Y, Ren L, Jiang Q, Liu X, Ji F, Zhang Y . Degeneration of saccular hair cells caused by MITF gene mutation. Neural Dev. 2019; 14(1):1. PMC: 6330439. DOI: 10.1186/s13064-019-0126-0. View

Bhat B, Singh A, Iqbal Z, Kaushik J, Rao A, Ahmad S . Comparative transcriptome analysis reveals the genetic basis of coat color variation in Pashmina goat. Sci Rep. 2019; 9(1):6361. PMC: 6478727. DOI: 10.1038/s41598-019-42676-y. View

Yu S, Wang G, Liao J, Tang M . Five alternative splicing variants of the TYR gene and their different roles in melanogenesis in the Muchuan black-boned chicken. Br Poult Sci. 2018; 60(1):8-14. DOI: 10.1080/00071668.2018.1533633. View

Posbergh C, Staiger E, Huson H . A Stop-Gain Mutation within Is Responsible for the Lilac Dilution Observed in Jacob Sheep. Genes (Basel). 2020; 11(6). PMC: 7349772. DOI: 10.3390/genes11060618. View

10.

Bauer A, Kehl A, Jagannathan V, Leeb T . A novel MLPH variant in dogs with coat colour dilution. Anim Genet. 2018; 49(1):94-97. DOI: 10.1111/age.12632. View

11.

Anello M, Daverio M, Silbestro M, Vidal-Rioja L, Di Rocco F . Characterization and expression analysis of KIT and MITF-M genes in llamas and their relation to white coat color. Anim Genet. 2019; 50(2):143-149. DOI: 10.1111/age.12769. View

12.

Utzeri V, Ribani A, Fontanesi L . A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit (Oryctolagus cuniculus). Anim Genet. 2014; 45(4):600-3. DOI: 10.1111/age.12171. View

13.

Fontanesi L, Tazzoli M, Beretti F, Russo V . Mutations in the melanocortin 1 receptor (MC1R) gene are associated with coat colours in the domestic rabbit (Oryctolagus cuniculus). Anim Genet. 2006; 37(5):489-93. DOI: 10.1111/j.1365-2052.2006.01494.x. View

14.

Honda A, Hirose M, Sankai T, Yasmin L, Yuzawa K, Honsho K . Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9. Exp Anim. 2014; 64(1):31-7. PMC: 4329513. DOI: 10.1538/expanim.14-0034. View

15.

Alshanbari F, Castaneda C, Juras R, Hillhouse A, Mendoza M, Gutierrez G . Comparative FISH-Mapping of , , and in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (). Front Genet. 2019; 10:340. PMC: 6477024. DOI: 10.3389/fgene.2019.00340. View

16.

Hu S, Zhai P, Chen Y, Zhao B, Yang N, Wang M . Morphological Characterization and Gene Expression Patterns for Melanin Pigmentation in Rex Rabbit. Biochem Genet. 2019; 57(5):734-744. DOI: 10.1007/s10528-019-09929-x. View

17.

Ishida Y, David V, Eizirik E, Schaffer A, Neelam B, Roelke M . A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat. Genomics. 2006; 88(6):698-705. DOI: 10.1016/j.ygeno.2006.06.006. View

18.

Li J, Chen W, Wu S, Ma T, Jiang H, Zhang Q . Differential expression of gene in Liaoning Cashmere goats with different coat colors. Anim Biotechnol. 2019; 30(3):273-278. DOI: 10.1080/10495398.2018.1485681. View

19.

Fontanesi L, Scotti E, Colombo M, Beretti F, Forestier L, DallOlio S . A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus). BMC Genet. 2010; 11:59. PMC: 3236303. DOI: 10.1186/1471-2156-11-59. View

20.

Yang L, Mo C, Shen W, Du X, Akbar Bhuiyan A, Li L . The recessive C locus in the MITF gene plays a key regulatory role in the plumage colour pattern of duck (Anas platyrhynchos). Br Poult Sci. 2019; 60(2):105-108. DOI: 10.1080/00071668.2018.1564237. View