Hepatocyte Nuclear Factor 4α and Cancer-related Cell Signaling Pathways: a Promising Insight into Cancer Treatment

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2021 Jan 19

PMID 33462379

Citations 23

Authors

Duo-Duo Lv

Ling-Yun Zhou

Hong Tang

Affiliations

Soon will be listed here.

Abstract

Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes. It controls the expression of functional genes and is also involved in the regulation of numerous cellular processes. A large number of studies have demonstrated that HNF4α is involved in many human malignancies. Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis. In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin, nuclear factor-κB, signal transducer and activator of transcription 3, and transforming growth factor β signaling pathways); and highlight potential clinical uses of HNF4α as a biomarker and therapeutic target for cancer.

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