Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2021 Jan 18

PMID 33456473

Citations 18

Authors

Meichen Liu

Kai Li

Yunyun Wang

Guoqing Zhao

Jinlan Jiang

Affiliations

Soon will be listed here.

Abstract

Neuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research on the treatment of NP by stem cells is increasing and promising results have been achieved in preclinical research. In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. We analyzed and summarized the general efficacy and mechanism of stem cells in the treatment of neuropathic pain. We found that the multiple-mechanism approach was different from the single mechanism of routine clinical drugs; stem cells play a role in peripheral mechanism, central mechanism, and disinhibition of spinal cord level that lead to neuropathic pain, so they are more effective in analgesia and treatment of neuropathic pain.

Citing Articles

Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled Trial.

Akhlaghpasand M, Tavanaei R, Hosseinpoor M, Heidari R, Mohammadi I, Chamanara M Cell Transplant. 2025; 34:9636897241298128.

PMID: 39874104 PMC: 11775971. DOI: 10.1177/09636897241298128.

Neuroinflammation mechanism underlying neuropathic pain: the role of mesenchymal stem cell in neuroglia.

Wijayanti I, Adnyana I, Widyadharma I, Wiratnaya I, Mahadewa T, Astawa I AIMS Neurosci. 2024; 11(3):226-243.

PMID: 39431272 PMC: 11486618. DOI: 10.3934/Neuroscience.2024015.

Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial.

Freitag J, Chamberlain M, Wickham J, Shah K, Cicuttini F, Wang Y Osteoarthr Cartil Open. 2024; 6(3):100500.

PMID: 39161739 PMC: 11331931. DOI: 10.1016/j.ocarto.2024.100500.

Exploring the Therapeutic Potential of Mesenchymal Stem Cells-derived conditioned medium: An In-depth Analysis of Pain Alleviation, Spinal CCL2 Levels, and Oxidative Stress.

Jaleh Z, Rahimi B, Shahrezaei A, Sohani M, Sagen J, Nasirinezhad F Cell Biochem Biophys. 2024; 82(3):2977-2988.

PMID: 39031248 DOI: 10.1007/s12013-024-01410-w.

Evaluating the effectiveness of neurofeedback in chronic pain management: a narrative review.

Diotaiuti P, Corrado S, Tosti B, Spica G, Di Libero T, DOliveira A Front Psychol. 2024; 15:1369487.

PMID: 38770259 PMC: 11104502. DOI: 10.3389/fpsyg.2024.1369487.

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