Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Overview

Journal Front Pharmacol

Date 2021 Jan 18

PMID 33456444

Citations 60

Authors

Md Habibur Rahman

Rokeya Akter

Tanima Bhattacharya

Mohamed M Abdel-Daim

Saad Alkahtani

Mohammed W Arafah

Norah S Al-Johani

Norah M Alhoshani

Nora Alkeraishan

Alhanof Alhenaky

Omar H Abd-Elkader

Hesham R El-Seedi

Deepak Kaushik

Vineet Mittal

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most experimental research on AD and resveratrol has been performed in many species, both and , during the last few years. Nevertheless, resveratrol's effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective molecular mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.

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