Proliferative and Anti-apoptotic Indices of Unicystic Ameloblastoma, Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Overview

Journal J Oral Maxillofac Pathol

Date 2021 Jan 18

PMID 33456257

Citations 4

Authors

Efetobo Victor Orikpete

Osawe Felix Omoregie

Michael Akin Ojo

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study is to compare the proliferative capacity and antiapoptotic capacity of unicystic ameloblastoma (UA), odontogenic keratocyst (OKC), dentigerous cyst (DC) and radicular cyst (RC) by assessing the Ki-67 labeling index (LI) and Bcl-2 LI, respectively.

Materials And Methods: Formalin-fixed, paraffin-embedded tissue blocks of twenty-three histopathologically diagnosed UAs, 6 OKCs, 8 DCs and 10 RCs were selected from the archival specimens. Five micrometer thick sections of tissue blocks of the lesions were processed for immunohistochemical staining with Ki-67 and Bcl-2. The Ki-67 LI and Bcl-2 LI were determined for the cases with a positive reaction.

Results: Ki-67 expression was seen in 6 (26.1%) cases of UA, 4 (66.7%) OKC, 1 (12.5%) DC and 1 (10.0%) RC. There was a statistically significant difference between the mean Ki-67 LI of UA and OKC ( = 0.024). Bcl-2 expression was seen in 16 (69.6%) UA, 5 (83.3%) OKC, 5 (62.5%) DC and 5 (50.0%) RC. The mean Bcl-2 LI of UA was significantly higher than that of DC ( = 0.048). Furthermore, cases of OKC had significantly higher mean Bcl-2 LI compared to DC ( = 0.026) and RC ( = 0.049).

Conclusion: This study suggests that the Ki-67 LI may help in differentiating OKC from UA. The Bcl-2 LI may be useful in differentiating UA from DCs, and differentiating OKC from DC and RC.

Citing Articles

A Comparative immunohistochemical analysis of epithelial-mesenchymal transition biomarkers in odontogenic keratocyst, dentigerous cyst, and radicular cyst.

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Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.

Almeida L, Loyd D, Boettcher D, Kraft O, Zammuto S Diagnostics (Basel). 2024; 14(12).

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Histopathologic spectrum and clinical correlation of lesions of jaw - a series of 60 cases.

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Maxillary unicystic ameloblastoma: a rare presentation.

Imase R, Watanabe T BMJ Case Rep. 2022; 15(11).

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