» Articles » PMID: 33454985

Pralatrexate for Refractory Mycosis Fungoides in Two Japanese Patients

Overview
Journal J Dermatol
Specialty Dermatology
Date 2021 Jan 17
PMID 33454985
Authors
Affiliations
Soon will be listed here.
Abstract

Pralatrexate has been approved for the treatment of relapsed/refractory peripheral T cell lymphomas. Studies in the U.S. also support the clinical efficacy of pralatrexate to treat advanced-stage cutaneous T-cell lymphomas, but outcomes in Japanese patients have not yet been reported. We herein describe two Japanese patients with heavily-pretreated relapsed/refractory mycosis fungoides that were successfully controlled by pralatrexate.

References
1.
Amengual J, Lichtenstein R, Lue J, Sawas A, Deng C, Lichtenstein E . A phase 1 study of romidepsin and pralatrexate reveals marked activity in relapsed and refractory T-cell lymphoma. Blood. 2017; 131(4):397-407. PMC: 5790128. DOI: 10.1182/blood-2017-09-806737. View

2.
Kitazume K, Akagawa Y, Wada S, Suzuki T, Fujita A . Pralatrexate for Prolonged Treatment of Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified, with Prophylactic Leucovorin. Case Rep Oncol. 2019; 12(2):529-536. PMC: 6696769. DOI: 10.1159/000501070. View

3.
OConnor O, Pro B, Pinter-Brown L, Bartlett N, Popplewell L, Coiffier B . Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study. J Clin Oncol. 2011; 29(9):1182-9. PMC: 3083873. DOI: 10.1200/JCO.2010.29.9024. View

4.
Foss F, Horwitz S, Coiffier B, Bartlett N, Popplewell L, Pro B . Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. Clin Lymphoma Myeloma Leuk. 2012; 12(4):238-43. DOI: 10.1016/j.clml.2012.01.010. View

5.
Olsen E, Whittaker S, Kim Y, Duvic M, Prince H, Lessin S . Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of.... J Clin Oncol. 2011; 29(18):2598-607. PMC: 3422534. DOI: 10.1200/JCO.2010.32.0630. View