Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jan 16

PMID 33451164

Citations 84

Authors

Antonino Maniaci

Giannicola Iannella

Salvatore Cocuzza

Claudio Vicini

Giuseppe Magliulo

Salvatore Ferlito

Giovanni Cammaroto

Giuseppe Meccariello

Andrea De Vito

Alice Nicolai

Annalisa Pace

Marco Artico

Samanta Taurone

Affiliations

Soon will be listed here.

Abstract

Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory sleep disorder characterised by repeated episodes of partial or complete obstruction of the upper airway during the night. This obstruction usually occurs with a reduction (hypopnea) or complete cessation (apnea) of the airflow in the upper airways with the persistence of thoracic-diaphragmatic respiratory movements. During the hypopnea/apnea events, poor alveolar ventilation reduces the oxygen saturation in the arterial blood (SaO) and a gradual increase in the partial arterial pressure of carbon dioxide (PaCO). The direct consequence of the intermittent hypoxia is an oxidative imbalance, with reactive oxygen species production and the inflammatory cascade's activation with pro and anti-inflammatory cytokines growth. Tumour necrosis factors, inflammatory cytokines (IL2, IL4, IL6), lipid peroxidation, and cell-free DNA have been found to increase in OSAS patients. However, even though different risk-related markers have been described and analysed in the literature, it has not yet been clarified whether specified inflammatory bio-markers better correlates with OSAS diagnosis and its clinical evolution/comorbidities. We perform a scientific literature review to discuss inflammatory and oxidative stress biomarkers currently tested in OSAS patients and their correlation with the disease's severity and treatment.

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