Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Jan 16

PMID 33451060

Authors

Alejandro Puet

Gema Dominguez

Francisco Javier Canada

Javier Perez-Castells

Affiliations

Soon will be listed here.

Abstract

Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the synthesis of new cyclopropane-containing piperidines bearing five stereogenic centers from natural amino acids l-serine and l-alanine. Those prepared from the latter amino acid may mimic l-fucose, a natural-occurring monosaccharide involved in many molecular recognition events. Final compounds prepared from l-serine bear configurations on the C5 position. The synthesis involved a stereoselective cyclopropanation reaction of an α,β-unsaturated piperidone, which was prepared through a ring-closing metathesis. The final compounds were tested as possible inhibitors of different glycosidases. The results, although, in general, with low inhibition activity, showed selectivity, depending on the compound and enzyme, and in some cases, an unexpected activity enhancement was observed.

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