Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone

Overview

Journal Stem Cell Reports

Publisher Cell Press

Specialty Cell Biology

Date 2021 Jan 15

PMID 33450189

Citations 14

Authors

Cristina Luongo

Lucile Butruille

Anthony Sebillot

Karine Le Blay

Markus Schwaninger

Heike Heuer

Barbara A Demeneix

Sylvie Remaud

Affiliations

Soon will be listed here.

Abstract

Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population is unknown, although TH availability determines proliferation and neuronal versus glial progenitor determination in murine subventricular zone (SVZ) NSCs. Mice display neurological signs of the severely disabling human disease, Allan-Herndon-Dudley syndrome, if they lack both MCT8 and OATP1C1 transporters, or MCT8 and deiodinase type 2. We analyzed the distribution of MCT8 and OATP1C1 in adult mouse SVZ. Both are strongly expressed in NSCs and at a lower level in neuronal cell precursors but not in oligodendrocyte progenitors. Next, we analyzed Mct8/Oatp1c1 double-knockout mice, where brain uptake of THs is strongly reduced. NSC proliferation and determination to neuronal fates were severely affected, but not SVZ-oligodendroglial progenitor generation. This work highlights how tight control of TH availability determines NSC function and glial-neuron cell-fate choice in adult brains.

Citing Articles

Thyroid hormone action in adult neurogliogenic niches: the known and unknown.

Valcarcel-Hernandez V, Mayerl S, Guadano-Ferraz A, Remaud S Front Endocrinol (Lausanne). 2024; 15:1347802.

PMID: 38516412 PMC: 10954857. DOI: 10.3389/fendo.2024.1347802.

Insights on the role of thyroid hormone transport in neurosensory organs and implication for the Allan-Herndon-Dudley syndrome.

Garcia-Aldea A, Guillen-Yunta M, Valcarcel-Hernandez V, Montero-Pedrazuela A, Guadano-Ferraz A, Barez-Lopez S Eur Thyroid J. 2024; 13(2).

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Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.

OShaughnessy K, Sasser A, Bell K, Riutta C, Ford J, Grindstaff R Toxicol Sci. 2023; 198(1):128-140.

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Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors.

Wu J, Wang Z, Xu H, Yang L, Liu J, Zheng Y Front Psychiatry. 2023; 14:1156481.

PMID: 37457778 PMC: 10348838. DOI: 10.3389/fpsyt.2023.1156481.

In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity.

Silva N, Campinho M Front Endocrinol (Lausanne). 2023; 14:1157685.

PMID: 37214246 PMC: 10194031. DOI: 10.3389/fendo.2023.1157685.

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