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Health-Related Quality of Life 10 Years After Liver Transplantation: A Longitudinal Retrospective Review

Overview
Specialty Radiology
Date 2021 Jan 15
PMID 33445652
Citations 2
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Abstract

As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8-3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014-2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement ( > 0.05) and did not change over four years ( > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social-emotional sub-domain ( = 0.03) and the child reported lower sub-domain scores related to coping and adjustment ( = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child-parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL.

Citing Articles

Avoidant Restrictive Food Intake Disorder in Pediatric Liver Transplant Patients.

Crest P, Stacey P, Accurso E, Deley C, Roberts J Pediatr Transplant. 2024; 29(1):e70014.

PMID: 39729541 PMC: 11677068. DOI: 10.1111/petr.70014.


Current state of medical tourism involving liver transplantation-the risk of infections and potential complications.

Neupane R, Taweesedt P, Anjum H, Surani S World J Hepatol. 2021; 13(7):717-722.

PMID: 34367493 PMC: 8326159. DOI: 10.4254/wjh.v13.i7.717.

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