and Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia

Overview

Journal Antioxidants (Basel)

Date 2021 Jan 15

PMID 33445495

Citations 4

Authors

Katarina Esih

Katja Goricar

Zvonka Rener-Primec

Vita Dolzan

Aneta Soltirovska-Salamon

Affiliations

Soon will be listed here.

Abstract

Inflammation and oxidative stress are recognized as important contributors of brain injury in newborns due to a perinatal hypoxic-ischemic (HI) insult. Genetic variability in these pathways could influence the response to HI and the outcome of brain injury. The aim of our study was to evaluate the impact of common single-nucleotide polymorphisms in the genes involved in inflammation and response to oxidative stress on brain injury in newborns after perinatal HI insult based on the severity and pattern of magnetic resonance imaging (MRI) findings. The DNA of 44 subjects was isolated from buccal swabs. Genotyping was performed for rs35829419, rs2043211, rs16944, rs1143623, rs1071676, rs1800629, rs1001179, rs4880, and rs1050450. Polymorphism in was found to be protective against HI brain injury detected by MRI overall findings. Polymorphisms in were associated with posterior limb of internal capsule, basal ganglia, and white matter brain patterns determined by MRI. Our results suggest a possible association between genetic variability in inflammation- and antioxidant-related pathways and the severity of brain injury after HI insult in newborns.

Citing Articles

Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study.

Chen X, Chen H, Jiang D Int J Gen Med. 2023; 16:537-545.

PMID: 36818762 PMC: 9936872. DOI: 10.2147/IJGM.S394202.

The NESHIE and CP Genetics Resource (NCGR): A database of genes and variants reported in neonatal encephalopathy with suspected hypoxic ischemic encephalopathy (NESHIE) and consequential cerebral palsy (CP).

Holborn M, Ford G, Turner S, Mellet J, van Rensburg J, Joubert F Genomics. 2022; 114(6):110508.

PMID: 36270382 PMC: 9726645. DOI: 10.1016/j.ygeno.2022.110508.

Genetic Variability of Inflammation and Oxidative Stress Genes Affects Onset, Progression of the Disease and Survival of Patients with Amyotrophic Lateral Sclerosis.

Ravnik-Glavac M, Goricar K, Vogrinc D, Koritnik B, Lavrencic J, Glavac D Genes (Basel). 2022; 13(5).

PMID: 35627142 PMC: 9140599. DOI: 10.3390/genes13050757.

Genetic Polymorphisms, Gene-Gene Interactions and Neurologic Sequelae at Two Years Follow-Up in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia.

Esih K, Goricar K, Soltirovska-Salamon A, Dolzan V, Rener-Primec Z Antioxidants (Basel). 2021; 10(9).

PMID: 34573127 PMC: 8465839. DOI: 10.3390/antiox10091495.

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