Mechanisms and Therapeutic Potential of Collateral Sensitivity to Antibiotics

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2021 Jan 14

PMID 33444399

Citations 25

Authors

Roderich Roemhild

Dan I Andersson

Affiliations

Soon will be listed here.

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References

Roemhild R, Linkevicius M, Andersson D . Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin. PLoS Biol. 2020; 18(1):e3000612. PMC: 7004380. DOI: 10.1371/journal.pbio.3000612. View

Santos-Lopez A, Marshall C, Scribner M, Snyder D, Cooper V . Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle. Elife. 2019; 8. PMC: 6814407. DOI: 10.7554/eLife.47612. View

Nichol D, Rutter J, Bryant C, Hujer A, Lek S, Adams M . Antibiotic collateral sensitivity is contingent on the repeatability of evolution. Nat Commun. 2019; 10(1):334. PMC: 6338734. DOI: 10.1038/s41467-018-08098-6. View

Blair J, Webber M, Baylay A, Ogbolu D, Piddock L . Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 2014; 13(1):42-51. DOI: 10.1038/nrmicro3380. View

Garcia-Quintanilla M, Carretero-Ledesma M, Moreno-Martinez P, Martin-Pena R, Pachon J, McConnell M . Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. Int J Antimicrob Agents. 2015; 46(6):696-702. DOI: 10.1016/j.ijantimicag.2015.07.017. View

Podnecky N, Fredheim E, Kloos J, Sorum V, Primicerio R, Roberts A . Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli. Nat Commun. 2018; 9(1):3673. PMC: 6131505. DOI: 10.1038/s41467-018-06143-y. View

Imamovic L, Sommer M . Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development. Sci Transl Med. 2013; 5(204):204ra132. DOI: 10.1126/scitranslmed.3006609. View

Imamovic L, Ellabaan M, Dantas Machado A, Citterio L, Wulff T, Molin S . Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections. Cell. 2018; 172(1-2):121-134.e14. PMC: 5766827. DOI: 10.1016/j.cell.2017.12.012. View

Barbosa C, Beardmore R, Schulenburg H, Jansen G . Antibiotic combination efficacy (ACE) networks for a Pseudomonas aeruginosa model. PLoS Biol. 2018; 16(4):e2004356. PMC: 5945231. DOI: 10.1371/journal.pbio.2004356. View

10.

Jansen G, Mahrt N, Tueffers L, Barbosa C, Harjes M, Adolph G . Association between clinical antibiotic resistance and susceptibility of Pseudomonas in the cystic fibrosis lung. Evol Med Public Health. 2016; 2016(1):182-94. PMC: 4906436. DOI: 10.1093/emph/eow016. View

11.

Mizusawa S, Gottesman S . Protein degradation in Escherichia coli: the lon gene controls the stability of sulA protein. Proc Natl Acad Sci U S A. 1983; 80(2):358-62. PMC: 393376. DOI: 10.1073/pnas.80.2.358. View

12.

Hernando-Amado S, Sanz-Garcia F, Luis Martinez J . Rapid and robust evolution of collateral sensitivity in antibiotic-resistant mutants. Sci Adv. 2020; 6(32):eaba5493. PMC: 7406369. DOI: 10.1126/sciadv.aba5493. View

13.

Huisman O, Dari R . An inducible DNA replication-cell division coupling mechanism in E. coli. Nature. 1981; 290(5809):797-9. DOI: 10.1038/290797a0. View

14.

Barbosa C, Trebosc V, Kemmer C, Rosenstiel P, Beardmore R, Schulenburg H . Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects. Mol Biol Evol. 2017; 34(9):2229-2244. PMC: 5850482. DOI: 10.1093/molbev/msx158. View

15.

Herencias C, Rodriguez-Beltran J, Leon-Sampedro R, Alonso-Del Valle A, Palkovicova J, Canton R . Collateral sensitivity associated with antibiotic resistance plasmids. Elife. 2021; 10. PMC: 7837676. DOI: 10.7554/eLife.65130. View

16.

Maltas J, Wood K . Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance. PLoS Biol. 2019; 17(10):e3000515. PMC: 6834293. DOI: 10.1371/journal.pbio.3000515. View

17.

Bryant D, McCalla D . Nitrofuran induced mutagenesis and error prone repair in Escherichia coli. Chem Biol Interact. 1980; 31(2):151-66. DOI: 10.1016/0009-2797(80)90002-2. View

18.

Rosenkilde C, Munck C, Porse A, Linkevicius M, Andersson D, Sommer M . Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase. Nat Commun. 2019; 10(1):618. PMC: 6365502. DOI: 10.1038/s41467-019-08529-y. View

19.

Yeh P, Hegreness M, Presser Aiden A, Kishony R . Drug interactions and the evolution of antibiotic resistance. Nat Rev Microbiol. 2009; 7(6):460-6. PMC: 2855488. DOI: 10.1038/nrmicro2133. View

20.

Roemhild R, Gokhale C, Dirksen P, Blake C, Rosenstiel P, Traulsen A . Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy. Proc Natl Acad Sci U S A. 2018; 115(39):9767-9772. PMC: 6166819. DOI: 10.1073/pnas.1810004115. View