Genomic Signatures of the Evolution of Defence Against Its Natural Enemies in the Poisonous and Medicinal Plant Datura Stramonium (Solanaceae)

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jan 14

PMID 33441607

Citations 10

Authors

I M De-la-Cruz

A Hallab

U Olivares-Pinto

R Tapia-Lopez

S Velazquez-Marquez

D Pinero

K Oyama

B Usadel

J Nunez-Farfan

Affiliations

Soon will be listed here.

Abstract

Tropane alkaloids and terpenoids are widely used in the medicine and pharmaceutic industry and evolved as chemical defenses against herbivores and pathogens in the annual herb Datura stramonium (Solanaceae). Here, we present the first draft genomes of two plants from contrasting environments of D. stramonium. Using these de novo assemblies, along with other previously published genomes from 11 Solanaceae species, we carried out comparative genomic analyses to provide insights on the genome evolution of D. stramonium within the Solanaceae family, and to elucidate adaptive genomic signatures to biotic and abiotic stresses in this plant. We also studied, in detail, the evolution of four genes of D. stramonium-Putrescine N-methyltransferase, Tropinone reductase I, Tropinone reductase II and Hyoscyamine-6S-dioxygenase-involved in the tropane alkaloid biosynthesis. Our analyses revealed that the genomes of D. stramonium show signatures of expansion, physicochemical divergence and/or positive selection on proteins related to the production of tropane alkaloids, terpenoids, and glycoalkaloids as well as on R defensive genes and other important proteins related with biotic and abiotic pressures such as defense against natural enemies and drought.

Citing Articles

Comparative transcriptome profiling reveals distinct regulatory responses of secondary defensive metabolism in species (Solanaceae) under plant development and herbivory-mediated stress.

Karinho Betancourt E, Calderon Cortes N, Tapia Lopez R, De-la-Cruz I, Nunez Farfan J, Oyama K Ecol Evol. 2024; 14(7):e11496.

PMID: 38983703 PMC: 11231941. DOI: 10.1002/ece3.11496.

A de novo long-read genome assembly of the sacred datura plant (Datura wrightii) reveals a role of tandem gene duplications in the evolution of herbivore-defense response.

Goldberg J, Olcerst A, McKibben M, Hare J, Barker M, Bronstein J BMC Genomics. 2024; 25(1):15.

PMID: 38166627 PMC: 10759348. DOI: 10.1186/s12864-023-09894-1.

Multiple independent losses of the biosynthetic pathway for two tropane alkaloids in the Solanaceae family.

Yang J, Wu Y, Zhang P, Ma J, Yao Y, Ma Y Nat Commun. 2023; 14(1):8457.

PMID: 38114555 PMC: 10730914. DOI: 10.1038/s41467-023-44246-3.

The chromosome-scale genome and the genetic resistance machinery against insect herbivores of the Mexican toloache, Datura stramonium.

De-la-Cruz I, Oyama K, Nunez-Farfan J G3 (Bethesda). 2023; 14(2).

PMID: 38113048 PMC: 10849327. DOI: 10.1093/g3journal/jkad288.

A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids.

Zhou W, Wang C, Hao X, Chen F, Huang Q, Liu T Plant Commun. 2023; 5(1):100680.

PMID: 37660252 PMC: 10811374. DOI: 10.1016/j.xplc.2023.100680.

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