ABO / Rh-D Blood Types and Susceptibility to Corona Virus Disease-19 in Peshawar, Pakistan

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2021 Jan 13

PMID 33437242

Citations 12

Authors

Fawad Rahim

Said Amin

Sher Bahadur

Mohammad Noor

Afsheen Mahmood

Huma Gul

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine the association between ABO/Rh-D blood types and susceptibility to SARS-CoV-2 infection in Pakistan.

Methods: In this cross-sectional study, 1935 confirmed cases of COVID-19 were included using consecutive sampling. Age and gender-matched sample of 1935 blood donors was used as a comparison group. Chi-square test and binary logistic regression were used for inferential statistics.

Results: Significantly higher proportion of blood type-B was observed in COVID-19 group (35.9% vs 31.9%, p=0.009). Blood type-AB was found more frequently (14.2% vs 11.8%, p=0.03) in the comparison group. The Rh-D Positive blood types were 93.3% in COVID-19 group and 94.9% in comparison group (p=0.03). The odds of blood type-B, AB and Rh-D positive to test positive for SARS-CoV-2 were 1.195 (95% CI 1.04 - 1.36, p=0.009), 0.80 (95% CI 0.66 - 0.97, p=0.03) and 0.75 (95% CI 0.57- 0.98, p = 0.03), respectively. Blood types A and O did not have significant association with SARS-CoV-2 PCR result (p = 0.22 and 0.88, respectively).

Conclusions: There is significant association between blood types B & AB and susceptibility to COVID-19. There is no association between blood types A and O with COVID-19. Rh- D positive blood types are less susceptible to COVID-19.

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